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1. (WO1997016441) SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016441 International Application No.: PCT/US1996/017324
Publication Date: 09.05.1997 International Filing Date: 28.10.1996
Chapter 2 Demand Filed: 13.05.1997
IPC:
C07D 401/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
DE LASZLO, Stephen, E. [US/US]; US (UsOnly)
MANTLO, Nathan, B. [US/US]; US (UsOnly)
Inventors:
DE LASZLO, Stephen, E.; US
MANTLO, Nathan, B.; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/007,12631.10.1995US
9602857.613.02.1996GB
Title (EN) SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
(FR) PYRROLES ARYLIQUES DE SUBSTITUTION, COMPOSITIONS RENFERMANT DE TELLES COMPOSES ET METHODES D'UTILISATION DE CES SUBSTANCES
Abstract:
(EN) The present invention addresses substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refer to diseases or conditions in which excessive or unregulated production of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation.
(FR) L'invention porte sur des pyrroles aryliques, des compositions renfermant de tels composés et des méthodes de traitement. Les maladies médiation par la cytokine englobent les maladies ou états pathologiques caractérisés par une production excessive ou déréglée d'une ou plusieurs cytokines. L'interleukine-1 (IL-1), l'interleukine-6 (IL-6), l'interleukine-8 (IL-8) et le facteur de nécrose tumorale sont des cytokines qui entrent en jeu dans l'immunorégulation et d'autres aspects physiologiques, comme l'inflammation.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074823