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1. (WO1997016403) PROCESS FOR THE SYNTHESIS OF CURCUMIN-RELATED COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016403 International Application No.: PCT/US1996/017524
Publication Date: 09.05.1997 International Filing Date: 01.11.1996
Chapter 2 Demand Filed: 20.05.1997
IPC:
C07C 45/74 (2006.01) ,C07C 49/248 (2006.01) ,C07C 49/255 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
67
by isomerisation; by change of size of the carbon skeleton
68
by increase in the number of carbon atoms
72
by reaction of compounds containing CO groups with the same or other compounds containing CO groups
74
combined with dehydration
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
20
Unsaturated compounds containing keto groups bound to acyclic carbon atoms
24
containing hydroxy groups
245
containing six-membered aromatic rings
248
having unsaturation outside the aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
20
Unsaturated compounds containing keto groups bound to acyclic carbon atoms
255
containing ether groups, groups, groups, or groups
Applicants:
GENEPRINT, INC. [US/US]; 15 Cynwyd Road Bala Cynwyd, PA 19004, US
Inventors:
KRACKOV, Mark, Harry; US
BELLIS, Harold, Edward; US
Agent:
LUTHER, John, P.; Duane, Morris & Heckscher LLP One Liberty Place Philadelphia, PA 19103-7396, US
Priority Data:
08/552,90403.11.1995US
Title (EN) PROCESS FOR THE SYNTHESIS OF CURCUMIN-RELATED COMPOUNDS
(FR) PROCEDE DE SYNTHESE DE COMPOSES ASSOCIES AU CURCUMIN
Abstract:
(EN) The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.
(FR) L'invention concerne un procédé de synthèse de curcumin et de composés à base de curcumin par réaction de la forme énole d'une 2,4-dicétone avec un aldéhyde monocarboxylique en présence d'un catalyseur amine organique. Les réactants sont dissous dans un solvant organique aprotique extrèmement polaire. Le produit à base de curcumin est récupéré sous forme cristalline par précipitation de la masse de réaction et recristallisation du solvant.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KP, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO19981974NZ321868MXPA/a/1998/003546SG53206EP0861223JPH11502232
CN1206396CA2236600KR1019990067279AU1996075510DK0861223