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1. (WO1997016191) INHIBITION OF AMYLOIDOSIS BY 9-ACRIDINONES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016191 International Application No.: PCT/US1996/016745
Publication Date: 09.05.1997 International Filing Date: 18.10.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
A61K 31/473 (2006.01) ,A61K 51/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
473
ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
Applicants:
WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US (AllExceptUS)
HAYS, Sheryl, Jeanne [US/US]; US (UsOnly)
LEVINE, Harry, III [US/US]; US (UsOnly)
SCHOLTEN, Jeffrey, David [US/US]; US (UsOnly)
Inventors:
HAYS, Sheryl, Jeanne; US
LEVINE, Harry, III; US
SCHOLTEN, Jeffrey, David; US
Agent:
RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
Priority Data:
60/006,38802.11.1995US
Title (EN) INHIBITION OF AMYLOIDOSIS BY 9-ACRIDINONES
(FR) INHIBITION DE L'AMYLOIDOSE PAR LES 9-ACRIDINONES
Abstract:
(EN) Amyloid aggregation in animals is inhibited by administering a 9-acridinone compound of formula (I), wherein R1 and R2 are hydrogen, halo, nitro, amino, hydroxy, trifluoromethyl, alkyl, alkoxy, and alkylthio; R3 is hydrogen or alkyl; and R4 is -alkylene-NR5R6. The compounds are especially useful in preventing and treating Alzheimer's disease.
(FR) On inhibe l'agrégation amyloïde chez l'animal en administrant un composé de 9-acridinone de formule (I), dans laquelle R1 et R2 sont hydrogène, halo, nitro, amino, hydroxy, trifluorométhyle, alkyle, alcoxy et alkylthio; R3 est hydrogène ou alkyle, et R4 est -alkylène-NR5R6. Ces composés sont particulièrement utiles dans la prévention et le traitement de la maladie d'Alzheimer.
Designated States: AL, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KE, KR, LK, LR, LS, LT, LV, MG, MK, MN, MW, MX, NO, NZ, PL, RO, SD, SG, SI, SK, TR, TT, UA, UG, US, UZ, VN
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US5972956AU1996074563