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1. (WO1997016190) ROTAMASE ENZYME ACTIVITY INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1997/016190 International Application No.: PCT/US1996/013624
Publication Date: 09.05.1997 International Filing Date: 26.08.1996
Chapter 2 Demand Filed: 23.04.1997
IPC:
A61K 31/444 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
444
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
Applicants:
GUILFORD PHARMACEUTICALS INC. [US/US]; 6611 Tributary Street Baltimore, MD 21224, US
Inventors:
STEINER, Joseph, P.; US
HAMILTON, Gregory, S.; US
Agent:
NATH, Gary, M.; Nath & Associates 1030 15th Street, N.W. 6th Floor Washington, DC 20005, US
Priority Data:
08/551,02631.10.1995US
08/645,14913.05.1996US
Title (EN) ROTAMASE ENZYME ACTIVITY INHIBITORS
(FR) INHIBITEURS DE L'ACTIVITE DE L'ENZYME ROTAMASE
Abstract:
(EN) This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
(FR) Cette invention concerne le procédé d'utilisation de composés de dérivé d'acide pipécolique neurotrophique spécifiquement formulés qui présentent une affinité pour les immunophilines du type FKBP en tant qu'inhibiteurs de l'activité enzymatique associée à des protéines d'immunophilines, et plus particulièrement comme inhibiteurs de l'activité enzymatique de peptidyl-prolyle isomérase ou rotamase pour stimuler ou favoriser la croissance ou la régénération neuronale.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)