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1. (WO1997016188) NOVEL INHIBITORS OF PEPTIDE BINDING TO MHC CLASS II PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016188 International Application No.: PCT/US1996/017134
Publication Date: 09.05.1997 International Filing Date: 25.10.1996
Chapter 2 Demand Filed: 19.02.1997
IPC:
A61K 38/00 (2006.01) ,C07C 237/22 (2006.01) ,C07D 213/82 (2006.01) ,C07K 5/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02
having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
22
having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81
Amides; Imides
82
in position 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
ADAMS, Alan, D. [US/US]; US (UsOnly)
JONES, A., Brian [US/US]; US (UsOnly)
Inventors:
ADAMS, Alan, D.; US
JONES, A., Brian; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/005,99430.10.1995US
9603240.416.02.1996GB
Title (EN) NOVEL INHIBITORS OF PEPTIDE BINDING TO MHC CLASS II PROTEINS
(FR) NOUVEAUX INHIBITEURS DE PEPTIDES SE LIANT AUX PROTEINES DE TYPE II DU CMH
Abstract:
(EN) Compounds of formula (I) are inhibitors of peptide binding to major histocompatibility complex type II proteins and may be used in the treatment and prevention of autoimmune diseases including: rheumatoid arthritis, Type I diabetes, multiple sclerosis, lupus erythematosis, Graves disease and pemphigus. The present invention also provides novel compositions, methods of treatment employing compounds of the present invention and methods of manufacture of the compounds of structural formula (I).
(FR) Cette invention concerne des composés représentés par la formule (I) qui sont des inhibiteurs des peptides se liant aux protéines de type II du complexe majeur d'histocompatibilité (CMH) et qui peuvent servir au traitement et à la prévention de maladies auto-immunes au nombre desquelles on compte la polyarthrite rhumatoïde, les diabètes de type I, la sclérose en plaques, le lupus érythémateux, le goitre exophtalmique et le pemphigus. La présente invention se rapporte en outre à de nouvelles compositions et à des procédés de traitement faisant usage de ces composés ainsi qu'à des procédés de fabrication des composés représentés par la formule (I).
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074753