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1. (WO1997016187) MUSCARINE ANTAGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016187 International Application No.: PCT/US1996/017214
Publication Date: 09.05.1997 International Filing Date: 28.10.1996
Chapter 2 Demand Filed: 21.05.1997
IPC:
C07D 401/12 (2006.01) ,C07D 403/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
THOMPSON, Wayne, J. [US/US]; US (UsOnly)
RANSOM, Richard, W. [US/US]; US (UsOnly)
MALLORGA, Pierre [FR/US]; US (UsOnly)
SUGRUE, Michael, F. [GB/US]; US (UsOnly)
MUNSON, Peter, M. [GB/US]; US (UsOnly)
Inventors:
THOMPSON, Wayne, J.; US
RANSOM, Richard, W.; US
MALLORGA, Pierre; US
SUGRUE, Michael, F.; US
MUNSON, Peter, M.; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/007,09731.10.1995US
9603835.123.02.1996GB
Title (EN) MUSCARINE ANTAGONISTS
(FR) ANTAGONISTE DE LA MUSCARINE
Abstract:
(EN) This invention is concerned with novel 1,3-dihydro-1-[1-(1-heteroarylpiperazin-4-yl)cyclohex-4-yl]-2H-benzimidazolones, derivatives thereof, their preparation, method of use and pharamceutical compositions. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).
(FR) Cette invention porte sur de nouveaux 1, 3-dihydro-1-[-1(1-hétéroarylpipérazine-4-yl) cyclohex-4-yl]-2H benzimidazolones, sur leurs dérivés, leur préparation et leur mode d'utilisation ainsi que sur des compositions pharmaceutiques. Ces composés, qui sont dotés d'une activité antimuscarinique, s'avèrent efficaces dans le traitement et/ou la prévention de la myopie.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996074784