Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1997016184) METHOD AND PHARMACEUTICAL COMPOSITION FOR REGULATING LIPID CONCENTRATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016184 International Application No.: PCT/US1996/015854
Publication Date: 09.05.1997 International Filing Date: 02.10.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
A61K 31/40 (2006.01) ,A61K 31/41 (2006.01) ,A61K 45/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applicants:
WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US (AllExceptUS)
BOCAN, Thomas, M., A. [US/US]; US (UsOnly)
Inventors:
BOCAN, Thomas, M., A.; US
Agent:
RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
MANSMANN, Ivo; Warner-Lambert Company Legal Division c/o Gödecke AG, Patents Mooswaldallee 1 D-79090 Freiburg, DE
Priority Data:
60/006,15502.11.1995US
Title (EN) METHOD AND PHARMACEUTICAL COMPOSITION FOR REGULATING LIPID CONCENTRATION
(FR) PROCEDE ET COMPOSITION PHARMACEUTIQUE VISANT A REGULER LA CONCENTRATION LIPIDIQUE
Abstract:
(EN) The present invention is a combination of an ACAT inhibitor, for example, sulfamic acid, [[2,4,6,-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester, and an HMG-CoA-reductase inhibitor, for example, atorvastatin, effective for lipid regulation. The combination of agents results in a greater reduction in plasma VLDL and LDL cholesterol and increases HDL cholesterol than either alone resulting in a less atherogenic lipoprotein profile. The combination is useful in the treatment of patients with or at risk of developing ischemic syndromes in order to restore endogenous vascular endothelium-dependent activities.
(FR) La présente invention se rapporte à une combinaison d'un inhibiteur d'ACAT tel que l'acide sulfamique, [[2,4,6,-tris(1-méthyléthyl)phényl]acétyl]-, 2,6-bis(1-méthyléthyl) phényl ester, et d'un inhibiteur de HMG-CoA-réductase tel que l'atorvastatine, efficace dans la régulation des lipides. La combinaison de ces agents entraîne une meilleure diminution du VLDL et LDL cholestérol plasmatique et élève davantage le taux de HDL cholestérol que l'un ou l'autre de ces agents administrés isolément, ce qui permet d'obtenir un profil lipoprotéinique moins athérogène. La combinaison est utilisée dans le traitement de patients présentant ou risquant de développer des syndromes ischémiques en vue de rétablir les activités endogènes dépendant de l'endothélium vasculaire.
Designated States: AL, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KE, KR, LK, LR, LS, LT, LV, MG, MK, MN, MW, MX, NO, NZ, PL, RO, SD, SG, SI, SK, TR, TT, UA, UG, US, UZ, VN
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1271IS4720NO19981961SK55798KR1020040029459SG53241
IL123902EP0858336US6124309JPH11515025 CN1201389CN1679953
CA2233558EA199800420KR1019990067270NZ319906NZ512484AU1996072539
IN2115/DEL/1996GEP20001898B