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1. (WO1997016176) ANGIOGENIC MATERIAL AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/016176 International Application No.: PCT/CA1996/000725
Publication Date: 09.05.1997 International Filing Date: 31.10.1996
Chapter 2 Demand Filed: 21.05.1997
IPC:
A61K 9/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
Applicants:
SEFTON, Michael, Vivian [CA/CA]; CA
BABENSEE, Julia, Elizabeth [CA/CA]; CA
MAY, Michael, Humphrey [CA/CA]; CA
Inventors:
SEFTON, Michael, Vivian; CA
BABENSEE, Julia, Elizabeth; CA
MAY, Michael, Humphrey; CA
Agent:
RICHES, McKENZIE & HERBERT; Suite 2900 2 Bloor Street East Toronto, Ontario M4W 3J5, CA
Priority Data:
2,161,86331.10.1995CA
Title (EN) ANGIOGENIC MATERIAL AND USES THEREOF
(FR) MATERIAU ANGIOGENIQUE ET SES UTILISATIONS
Abstract:
(EN) An angiogenic material is disclosed which promotes extensive vascularization when implanted in animal tissue. The angiogenic material is preferably used in microcapsule coatings and microspheres for implantation in animals. In microcapsules, the angiogenic material promotes better exchange of nutrients, waste products and cellular products between encapsulated cells and the circulatory system of the host animal. Microspheres containing the angiogenic material may be used to assist in recovery of ischemic heart muscle by injection of the microspheres into the heart muscle or blood vessels serving the ischemic area. Also disclosed is a method of forming small microcapsules and microspheres by passing cell aggregates or air bubbles through layers of a density gradient.
(FR) L'invention concerne un matériau angiogénique favorisant une vascularisation importante quand on l'implante dans un tissu animal. On utilise, de préférence, ce matériau angiogénique dans des revêtement en microcapsules et dans des microsphères, afin de les implanter chez l'animal. Ce matériau angiogénique en microcapsules favorise un meilleur échange d'agents nutritifs, de déchets de produits cellulaires entre les cellules encapsulées et le système circulatoire de l'animal. On peut utiliser des microsphères contenant le matériau angiogénique, afin d'aider au rétablissement du muscle cardiaque ischémique par injection des microsphères dans le muscle cardiaque ou dans les vaisseaux sanguins desservant la zone ischémique. Elle concerne également un procédé de formation de petites microcapsules et de petites microsphères consistant à faire passer des agrégats cellulaires ou des bulles d'air à travers des couches d'un gradient de densité.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US6261585US20020037308AU1996072742