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1. (WO1997015689) METHOD TO DETECT POLYMORPHISM IN THE S182 GENE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015689 International Application No.: PCT/US1996/017132
Publication Date: 01.05.1997 International Filing Date: 25.10.1996
Chapter 2 Demand Filed: 20.05.1997
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE [US/US]; 660 South Euclid Avenue St. Louis, MO 63110, US (AllExceptUS)
UNIVERSITY OF SOUTH FLORIDA [US/US]; 4204 East Flower Avenue Tampa, FL 33620, US (AllExceptUS)
HARDY, John, A. [GB/US]; US (UsOnly)
GOATE, Alison, M. [GB/US]; US (UsOnly)
Inventors:
HARDY, John, A.; US
GOATE, Alison, M.; US
Agent:
HAN, William, T. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
60/007,04825.10.1995US
Title (EN) METHOD TO DETECT POLYMORPHISM IN THE S182 GENE
(FR) METHODE DE DETECTION DE POLYMORPHISME DANS LE GENE S182
Abstract:
(EN) A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.
(FR) L'invention concerne une méthode de détection de polymorphismes dans le gène S182, qui consiste à détecter les mutations dans ledit gène au moyen d'amorces pour PCR non appariées et sélectionnées, comprenant des séquences dérivées de séquences introniques du gène S182. Une méthode d'identification d'un individu susceptible de contracter de manière tardive la maladie d'Alzheimer est également décrite.
Designated States: AL, AM, AU, BB, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KG, KP, KR, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0874911JPH11500321 CA2235611AU1996074752