Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1997015680) CATIONIC POLYACRYLATES AND POLY(ALKYL) ACRYLATES OR THE CORRESPONDING ACRYLAMIDES FOR USE IN SYNTHETIC TRANSFECTION OR BLOCKING SYSTEMS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015680 International Application No.: PCT/NL1996/000416
Publication Date: 01.05.1997 International Filing Date: 25.10.1996
Chapter 2 Demand Filed: 23.04.1997
IPC:
A61K 47/48 (2006.01) ,C12N 15/87 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Applicants:
OCTOPLUS B.V. [NL/NL]; Niels Bohrweg 11-13 NL-2333 CA Leiden, NL (AllExceptUS)
HENNINK, Wilhelmus, Everhardus [NL/NL]; NL (UsOnly)
VAN DE WETERING, Petra [NL/NL]; NL (UsOnly)
Inventors:
HENNINK, Wilhelmus, Everhardus; NL
VAN DE WETERING, Petra; NL
Agent:
SMULDERS, Th., A., H., J.; Vereenigde Octrooibureaux Nieuwe Parklaan 97 NL-2587 BN The Hague, NL
Priority Data:
60/005,92327.10.1995US
95202891.825.10.1995EP
Title (EN) CATIONIC POLYACRYLATES AND POLY(ALKYL) ACRYLATES OR THE CORRESPONDING ACRYLAMIDES FOR USE IN SYNTHETIC TRANSFECTION OR BLOCKING SYSTEMS
(FR) POLY(C1-6 ALKYL)ACRYLATES ET POLYACRYLATES CATIONIQUES ET ACRYLAMIDES CORRESPONDANTS A UTILISER DANS DES SYSTEMES DE TRANSFECTION SYNTHETIQUE OU BLOQUANTS
Abstract:
(EN) The present invention relates to a synthetic transfection or blocking system comprising as a carrier a cationic, water soluble or water dispersible polyacrylate, a polyacrylamide, a poly(C1-6 alkyl)acrylate, or a poly(C1-6 alkyl)acrylamide. In addition, it relates to a method for introducing DNA fragments in target cells, comprising contacting these DNA fragments with a polyacrylate, polyacrylamide, a poly(C1-6 alkyl)acrylate or a poly(C1-6 alkyl)acrylamide, which is at least partially substituted with cationic substituents and subsequently contacting the obtained transfection system with target cells. Finally, the invention involves the use of a polyacrylate, a polyacrylamide, a poly(C1-6 alkyl)acrylate, or a poly(C1-6 alkyl)acrylamide, which is at least partially substituted with cationic substituents as a DNA carrier system.
(FR) L'invention concerne un système de transfection synthétique ou bloquant comprenant, en tant que support, un polyacrylate, un polyacrylamide, un poly(C1-6 alkyl)acrylate ou un poly(C1-6 alkyl)acrylamide cationiques, hydrosolubles ou dispersibles dans l'eau. De plus, elle concerne un procédé d'introduction de fragments d'ADN dans des cellules cibles, qui consiste à mettre ces fragments d'ADN en contact avec un polyacrylate, un polyacrylamide, un poly(C1-6 alkyl)acrylate ou un poly(C1-6 alkyl)acrylamide, au moins partiellement substitué par des substituants cationiques, puis à mettre le système de transfection obtenu en contact avec des cellules cibles. Enfin, l'invention concerne l'utilisation d'un polyacrylate, d'un polyacrylamide, d'un poly(C1-6 alkyl)acrylate ou d'un poly(C1-6 alkyl)acrylamide, au moins partiellement substitué par des substituants cationiques en tant que système de support d'ADN.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0859857US5985573JP2001508641 AU1996073422