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1. (WO1997015679) RECOMBINANT VIRUSES CONTAINING MOBILE GENETIC ELEMENTS AND METHODS OF USE IN GENE THERAPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015679 International Application No.: PCT/US1996/017176
Publication Date: 01.05.1997 International Filing Date: 24.10.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
C07K 14/16 (2006.01) ,C12N 15/00 (2006.01) ,C12N 15/861 (2006.01) ,C12N 15/867 (2006.01) ,C12N 15/90 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16
HIV-1
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90
Stable introduction of foreign DNA into chromosome
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 133 South 36th Street Philadelphia, PA 19104-3246, US (AllExceptUS)
KELLEY, William, Mark [US/US]; US (UsOnly)
WILSON, James, M. [US/US]; US (UsOnly)
Inventors:
KELLEY, William, Mark; US
WILSON, James, M.; US
Agent:
BAK, Mary, E. ; Howson and Howson Spring House Corporate Center Spring House, PA 19477, US
Priority Data:
60/005,94227.10.1995US
Title (EN) RECOMBINANT VIRUSES CONTAINING MOBILE GENETIC ELEMENTS AND METHODS OF USE IN GENE THERAPY
(FR) VIRUS RECOMBINES CONTENANT DES ELEMENTS GENETIQUES MOBILES ET PROCEDES D'UTILISATION DESDITS VIRUS EN THERAPIE GENIQUE
Abstract:
(EN) Recombinant E1-deleted adenoviruses are provided that contain a transgene associated with the elements of a recombinant transposon sequence, e.g., from Moloney murine leukemia virus (Mo-MLV), necessary to achieve specific retrotransposition of the transgene from the recombinant adenovirus into the target cell chromatin. Also provided are methods for generating the recombinant adenoviruses and methods of use thereof.
(FR) L'invention concerne des adénovirus recombinés, avec délétion de E1, qui contiennent un transgène associé aux éléments d'une séquence de transposon recombiné, par ex., provenant du virus de la leucémie murine de Moloney (Mo-MLV), nécessaire pour effectuer une rétrotransposition spécifique du transgène à partir de l'adénovirus recombiné dans la chromatine de la cellule cible. L'invention concerne également des procédés de production desdits adénovirus recombinés et leurs procédés d'utilisation.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996076653