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1. (WO1997015599) NOVEL ACETALDEHYDE AND MALONDIALDEHYDE PROTEIN ADDUCTS AS MARKERS FOR ALCOHOL LIVER DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015599 International Application No.: PCT/US1996/017833
Publication Date: 01.05.1997 International Filing Date: 25.10.1996
Chapter 2 Demand Filed: 16.05.1997
IPC:
C07K 14/76 (2006.01) ,C07K 16/18 (2006.01) ,C07K 16/44 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
76
Albumins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44
against material not provided for elsewhere
Applicants:
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US/US]; 3835 Holdrege Street Lincoln, NE 68503, US (AllExceptUS)
THIELE, Geoffrey, M. [US/US]; US (UsOnly)
McDONALD, Thomas, L. [US/US]; US (UsOnly)
TUMA, Dean, J. [US/US]; US (UsOnly)
KLASSEN, Lynell, W. [US/US]; US (UsOnly)
SORRELL, Michael, F. [US/US]; US (UsOnly)
Inventors:
THIELE, Geoffrey, M.; US
McDONALD, Thomas, L.; US
TUMA, Dean, J.; US
KLASSEN, Lynell, W.; US
SORRELL, Michael, F.; US
Agent:
NEBEL, Heidi, S.; Zarley, McKee, Thomte, Voorhees & Sease Suite 3200 801 Grand Avenue Des Moines, IA 50309-2721, US
Priority Data:
60/005,92927.10.1995US
Title (EN) NOVEL ACETALDEHYDE AND MALONDIALDEHYDE PROTEIN ADDUCTS AS MARKERS FOR ALCOHOL LIVER DISEASE
(FR) NOUVEAU PRODUITS D'ADDITION PROTEINIQUES A BASE D'ACETALDEHYDE ET DE MALONDIALDEHYDE SERVANT DE MARQUEURS POUR LA CIRRHOSE ALCOOLIQUE
Abstract:
(EN) A novel protein adduct is disclosed which is associated with the presence of alcohol liver disease. The adduct is a hybrid product of malondialdehyde and acetaldehyde which act synergistically to bind hepatic proteins. The adduct is highly immunogenic and fluorescent. Methods of detection are also disclosed including monoclonal and polyclonal antibodies.
(FR) Ce nouveau produit d'addition protéinique est associé à la présence d'une cirrhose alcoolique et il constitue un produit hybride constitué d'un malondialdéhyde et d'un acétaldéhyde qui agissent de façon synergique pour se lier aux protéines hépatiques. Ce produit d'addition est hautement immunogène et fluorescent. On décrit aussi des procédés de détection faisant appel à des anticorps monoclonaux et polyclonaux.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US5939535AU1997011173