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1. (WO1997015598) NOVEL PEPTIDE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015598 International Application No.: PCT/JP1996/003080
Publication Date: 01.05.1997 International Filing Date: 23.10.1996
Chapter 2 Demand Filed: 30.04.1997
IPC:
A61K 38/00 (2006.01) ,C07K 7/06 (2006.01) ,C07K 7/08 (2006.01) ,C07K 14/47 (2006.01) ,C07K 14/745 (2006.01) ,C07K 14/81 (2006.01) ,C07K 19/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
81
Protease inhibitors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
Applicants:
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE [JP/JP]; 6-1, Okubo 1-chome Kumamoto-shi Kumamoto 860, JP (AllExceptUS)
NAKAHARA, Yo [JP/JP]; JP (UsOnly)
HARA, Saburo [JP/JP]; JP (UsOnly)
KAMIKUBO, Yuichi [JP/JP]; JP (UsOnly)
TAKEMOTO, Sumiyo [JP/JP]; JP (UsOnly)
MIYAMOTO, Seiji [JP/JP]; JP (UsOnly)
Inventors:
NAKAHARA, Yo; JP
HARA, Saburo; JP
KAMIKUBO, Yuichi; JP
TAKEMOTO, Sumiyo; JP
MIYAMOTO, Seiji; JP
Agent:
AOYAMA, Tamotsu ; Aoyama & Partners IMP Building 3-7, Shiromi 1-chome Chuo-ku, Osaka-shi Osaka 540, JP
Priority Data:
7/30079224.10.1995JP
Title (EN) NOVEL PEPTIDE
(FR) NOUVEAU PEPTIDE
Abstract:
(EN) A peptide containing (A) a peptide consisting of an amino acid sequence rich in basic amino acids and (B) another peptide consisting of an amino acid sequence containing at least two consecutive hydrophobic amino acid residues wherein the peptide (B) is bonded directly or via an amino acid sequence consisting of several amino acids to the C-terminus of the peptide (A). This novel peptide has an excellent inhibitory effect on the proliferation of smooth muscle fibers and preparations containing the peptide are efficacious in the prevention or treatment of arterial sclerosis accompanying the proliferation of smooth muscle fibers, restenosis after angioplasty, luminal stenosis after vascular transplantation, and leiomyosarcoma.
(FR) L'invention porte sur un peptide contenant: un peptide formé d'une séquence d'acides aminés riche en acides aminés de base; et (B) un deuxième peptide formé d'une séquence d'acides aminés contenant au moins deux résidus consécutifs d'acides aminés hydrophobes. Le peptide (B) est fixé directement ou par l'intermédiaire d'une séquence de plusieurs acides aminés à l'extrémité C-terminale du peptide (A). Ce nouveau peptide a d'excellents effets inhibiteurs sur la prolifération des fibres de muscles lisses et les préparations le contenant sont efficaces pour la prévention ou le traitement de l'artériosclérose accompagnant la prolifération des fibres de muscles lisses, la resténose faisant suite à une angioplastie, la sténose faisant suite à une transplantation vasculaire, et le léiomyosarcome.
Designated States: AU, CA, JP, KR, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP0867450US6191113JP3930050CA2232240KR1019990066965AU1996073357