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1. WO1997015597 - HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE

Publication Number WO/1997/015597
Publication Date 01.05.1997
International Application No. PCT/NL1996/000414
International Filing Date 24.10.1996
Chapter 2 Demand Filed 21.05.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
Applicants
  • CENTOCOR B.V. [NL]/[NL] (AllExceptUS)
  • WARNAAR, Sven, Olle [NL]/[NL] (UsOnly)
  • MELIEF, Cornelis, Joseph, Maria [NL]/[NL] (UsOnly)
  • RAS, Elisabeth [NL]/[NL] (UsOnly)
  • LITVINOV, Sergey, Victor [NL]/[NL] (UsOnly)
Inventors
  • WARNAAR, Sven, Olle
  • MELIEF, Cornelis, Joseph, Maria
  • RAS, Elisabeth
  • LITVINOV, Sergey, Victor
Agents
  • SMULDERS, Th., A., H., J.
Priority Data
95202893.425.10.1995EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN EPITHELIAL ANTIGEN Ep-CAM DERIVED PEPTIDES AND THEIR USE
(FR) PEPTIDES DERIVES DE L'Ep-CAM ANTIGENE EPITHELIAL HUMAIN ET LEUR EMPLOI
Abstract
(EN)
Peptides comprising an amino acid sequence which has the ability to bind to human Major Histocompatibility Complex (MHC) Class I molecules, in particular the MHC Class I allele HLA-A*0201, and especialy those peptides that are capable of inducing a primary cytotoxic T lymphocyte (CTL) response. The amino acid sequence is derived from the protein Ep-CAM. The peptides are useful for treatment or prophylaxis of Ep-CAM positive cells, in particular Ep-CAM associated cancers, for in vivo or in vitro induction of CTLs that are effective against Ep-CAM positive tumor cells, and for diagnostic purposes.
(FR)
La présente invention concerne des peptides comportant une séquence d'acide aminé qui possède la capacité de fixer les molécules humaines de classe I du complexe majeur d'histocompatibilité (CMH), en particulier l'allèle de classe I du CMH HLA-A*0201, spécialement ceux des peptides qui sont capables d'induire une réaction des lymphocytes T cytotoxiques (LTC) primaires. La séquence d'acide aminé est dérivée de la protéine Ep-CAM. Les peptides en question sont utiles pour le traitement ou la prophylaxie de cellules positives pour l'Ep-CAM, notamment les cancers associés à l'Ep-CAM, pour l'induction in vivo ou in vitro de LTC qui sont efficaces contre les cellules tumorales positives pour l'Ep-CAM, et à des fins diagnostiques.
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