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1. WO1997015578 - PAPYRACILLIC ACID, METHOD FOR PREPARATION AND ITS USE AS SYNTHON FOR BIOACTIVE SUBSTANCES

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[ EN ]

Claims

1. Compound ofthe formula (I)


its tautomers, optically active forms, and their pharmacologically acceptable salts.

2. Derivates of compound I ofthe formula (!')



r

where R represents a branched or unbranched alky group and its tautomers, optically active forms and their pharmaceutically acceptable salts.

3. A method for the preparation of compounds I of claim 1 which comprises culturing of a strain belonging to genus Ascomyces which produces substances according to claim 1 in a nutrient medium containing in addition CaBr2.

4. A method as claimed in claim 3, wherein the substance producing strain is Ascomecetes Lachnum papyraceum (Karst.) Karst. strain 44 ~ 88.

5. Method of making a compound plurality by reaction of compound I of claim 1 or compound I' of claim 2 with one or more nucleophils Y.

6. Method of making a compound plurality by a reaction of compound II,


H
its tautomers or optically active forms with one or more nucleophils Y.

7. A method of reducing a compound plurality obtainable by a method of any one of claims 5 or 6 by separation of a subplurality of compounds by conventional means.

8. A method of isolating a single compound comprising

a) providing a compound plurality obtainable by a method of any one of claims 5, 6 or 7 b) isolating said compound from said compound plurality by conventional means.

9. A method of determining whether a compound or compound plurality
obtainable by a method of any one of claims 5-8 interact with a target of interest which comprises

a) providing a target of interest,
b) incubating said target with said compound or compound plurality and c) determining whether said target exhibits a responsive change

10. A method for identifying a pharmacophor by using a compound or compound plurality obtainable by the method of any one of claims 5-8 which comprises

a) providing a target of interest,
b) incubating said target with said compound or compound plurality, c) determining whether said target exhibits a responsive change, d) variation ofthe structure of said compound or compound plurality
whereby the responsive change may not be reduced.

11. A method of claim 10 comprising an additional step
e) repeating steps a) to d) using the identified pharmacophor obtainable by a method of claim 10 instead ofthe compound or compound plurality.

12. Compound or compound plurality obtainable by the method of any one of claims 3 to 11.

13. A single compound obtainable by the method of any one of claims 3, 4, 8, 10 or 11 for use in medicine.

15. A method of making a pharmaceutical composition comprising

combining a compound obtainable by the method of any one of claims 3-5 or 8-11 and a pharmaceutical acceptable carrier, where said pharmaceutical composition shows a fibrinogen-lowering, antibacterial, antifungal or cytotoxic activity.