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1. (WO1997015330) HYALURONIC ACID AS DNA CARRIER FOR GENE THERAPY AND VEGF ANTISENSE DNA TO TREAT ABNORMAL RETINAL VASCULARIZATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015330 International Application No.: PCT/AU1996/000664
Publication Date: 01.05.1997 International Filing Date: 22.10.1996
Chapter 2 Demand Filed: 01.05.1997
IPC:
A61K 47/36 (2006.01) ,A61K 47/48 (2006.01) ,A61K 48/00 (2006.01) ,C07K 14/52 (2006.01) ,C12N 15/11 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
HYAL PHARMACEUTICAL AUSTRALIA LIMITED [AU/AU]; Level 2 44A Kings Park Road West Perth, W.A. 6009, AU (AllExceptUS)
RAKOCZY, Piroska, Elizabeth [AU/AU]; AU (UsOnly)
CONSTABLE, Ian, Jeffrey [AU/AU]; AU (UsOnly)
Inventors:
RAKOCZY, Piroska, Elizabeth; AU
CONSTABLE, Ian, Jeffrey; AU
Agent:
SANTER, Vivien; Griffith Hack 509 St. Kilda Road Melbourne, VIC 3004, AU
Priority Data:
PN 616123.10.1995AU
PN 904701.04.1996AU
Title (EN) HYALURONIC ACID AS DNA CARRIER FOR GENE THERAPY AND VEGF ANTISENSE DNA TO TREAT ABNORMAL RETINAL VASCULARIZATION
(FR) ACIDE HYALURONIQUE UTILISE COMME PORTEUR D'ADN POUR UNE THERAPIE GENIQUE ET ADN ANTI-SENS DU FACTEUR DE CROISSANCE DE L'ENDOTHELIUM VASCULAIRE POUR LE TRAITEMENT D'UNE VASCULARISATION ANORMALE DE LA RETINE
Abstract:
(EN) The invention provides methods and compositions for gene therapy, including antisense therapy. In one embodiment, the compositions comprise hyaluronic acid to promote uptake of nucleic acid by the target cells. The invention is illustrated with reference to treatment of retinal diseases caused by neovascularisation.
(FR) Cette invention porte sur des méthodes de thérapie génique ainsi que sur les compositions correspondantes, y compris une thérapie anti-sens. Dans un mode de réalisation, les compositions contiennent de l'acide hyaluronique afin de stimuler l'absorption d'acide nucléique par les cellules cibles. A titre d'exemple, cette invention trouve une application dans le traitement de maladies rétiniennes causées par une néoformation de vaisseaux sanguins.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
SG53164EP0859636JP2000507915CN1209068CA2235685KR1019990066967
NZ320006AU1996072664