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1. (WO1997015327) METHODS OF TREATING ESTABLISHED COLITIS USING ANTIBODIES AGAINST IL-12
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015327 International Application No.: PCT/US1996/004337
Publication Date: 01.05.1997 International Filing Date: 29.03.1996
Chapter 2 Demand Filed: 23.05.1997
IPC:
A61K 38/00 (2006.01) ,C07K 16/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
Applicants:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer, Box OTT Bethesda, MD 20892-9902, US
Inventors:
STROBER, Warren; US
FUSS, Ivan; US
NEURATH, Markus; DE
Agent:
NEEDLE, William, H. ; Needle & Rosenberg Suite 1200 127 Peachtree Street, N.E. Atlanta, GA 30303-1811, US
Priority Data:
08/547,97925.10.1995US
Title (EN) METHODS OF TREATING ESTABLISHED COLITIS USING ANTIBODIES AGAINST IL-12
(FR) PROCEDE DE TRAITEMENT DE LA COLITE CHRONIQUE A L'AIDE D'ANTICORPS CONTRE IL-12
Abstract:
(EN) The present invention provides a method for treating the inflammatory response of an established colitis in a subject with inflammatory bowel disease (IBD) comprising administering to a subject diagnosed with an established colitis from an IBD an amount of an antibody to interleukin-12 effective in reducing the colitis-inducing effect of interleukin-12. Also provided is a method for screening a substance for its effectiveness in reducing the inflammatory response of an established colitis. Additionally, the present invention provides a method for screening a substance for its effectiveness in preventing inflammatory bowel disease.
(FR) La présente invention se rapporte à un procédé de traitement de la réaction inflammatoire d'une colite chronique chez un sujet atteint d'une affection intestinale inflammatoire. Ce procédé consiste à administrer à un sujet, dont on a diagnostiqué une colite chronique due à une affection intestinale inflammatoire, une quantité d'un anticorps contre l'interleukine-12 efficace pour réduire l'effet de l'interleukine-12 provoquant la colite. L'invention se rapporte également à un procédé de criblage d'une substance sélectionnée pour son efficacité dans la réduction de la réaction inflammatoire d'une colite chronique. La présente invention se rapporte en outre à un procédé de criblage d'une substance sélectionnée pour son efficacité dans la prévention des affections intestinales inflammatoires.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862461JP2000502991 CA2235866AU1996053786