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1. (WO1997015319) METHOD AND PHARMACEUTICAL COMPOSITION FOR CHONDROSTIMULATION WITH A PROSTAGLANDIN (E.G. MISOPROSTOL) AND TGF-BETA, OPTIONALLY IN COMBINATION WITH IGF-1
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015319 International Application No.: PCT/CA1996/000698
Publication Date: 01.05.1997 International Filing Date: 23.10.1996
IPC:
A61K 38/18 (2006.01) ,A61K 38/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
30
Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
Applicants:
QUEEN'S UNIVERSITY AT KINGSTON [CA/CA]; Kingston, Ontario K7L 3N6, CA (AllExceptUS)
ANASTASSIADES, Tassos [CA/CA]; CA (UsOnly)
Inventors:
ANASTASSIADES, Tassos; CA
Agent:
STAUSS, Karen; McFadden, Fincham Suite 606 225 Metcalfe Street Ottawa, Ontario K2P 1P9, CA
Priority Data:
60/005,79023.10.1995US
Title (EN) METHOD AND PHARMACEUTICAL COMPOSITION FOR CHONDROSTIMULATION WITH A PROSTAGLANDIN (E.G. MISOPROSTOL) AND TGF-BETA, OPTIONALLY IN COMBINATION WITH IGF-1
(FR) PROCEDE ET COMPOSITION PHARMACEUTIQUE UTILISEE DANS LA CHONDROSTIMULATION AVEC UNE PROSTAGLANDINE (PAR EX. MISOPROSTOL) ET TGF-BETA, EVENTUELLEMENT COMBINE A IGF-1
Abstract:
(EN) A pharmaceutical composition comprising a prostaglandin having structure (I) and a compound chosen from the group consisting of TGF-$g(b) and IGF-1 wherein the prostaglandin, TGF-$g(b) and IGF-1 are present in an amount effective to stimulate the production of chondrocyte matrix or prevent the degeneration of chondrocyte matrix; and methods of stimulating the production, or preventing the degeneration, of chondrocyte matrix or cartilage matrix in a subject in need thereof by administration of a combination of the prostaglandin and TGF-$g(b) or a combination of the prostaglandin, TGF-$g(b) and IGF-1.
(FR) L'invention se rapporte à une composition pharmaceutique comprenant une prostaglandine et ayant la structure (I), et un composé sélectionné dans le groupe constitué par TGF-$g(b) et IGF-1. La prostaglandine, TGF-$g(b) et IGF-1 sont présents dans une quantité efficace afin de stimuler la production de la matrice du chondrocyte ou d'empêcher la dégénération de la matrice du chondrocyte. L'invention se rapporte également à des procédés visant à stimuler la production ou empêcher la dégénération de la matrice de chondrocyte ou de la matrice du cartilage chez un sujet et consistant à administrer une combinaison de prostaglandine et de TGF-$g(b) ou une combinaison de prostaglandine, de TGF-$g(b) et d'IGF-1.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996072719