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1. (WO1997015317) GnRH/REDUCED PSEUDOMONAS EXOTOXIN CONJUGATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015317 International Application No.: PCT/US1996/017041
Publication Date: 01.05.1997 International Filing Date: 23.10.1996
Chapter 2 Demand Filed: 13.05.1997
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,A61K 47/48 (2006.01) ,C07K 7/23 (2006.01) ,C07K 14/21 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
23
Luteinising hormone-releasing hormone (LHRH); Related peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
21
from Pseudomonadaceae (F)
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
TOLMAN, Richard, L. [US/US]; US (UsOnly)
LOMBARDO, Victoria, K. [US/US]; US (UsOnly)
Inventors:
TOLMAN, Richard, L.; US
LOMBARDO, Victoria, K.; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/005,89927.10.1995US
Title (EN) GnRH/REDUCED PSEUDOMONAS EXOTOXIN CONJUGATES
(FR) CONJUGUES GnRH/EXOTOXINE DE PSEUDOMONAS REDUITE
Abstract:
(EN) Conjugates of GnRH are constructed from GnRH or an analog thereof, a reduced Pseudomonas exotoxin, or a variant thereof, and a unique linking group. The conjugates are administered to male and female animals to sterilize said animals or to reduce tumors that require sex steroids for growth. The instant conjugates are therefore useful as sterilizing agents and anticancer agents.
(FR) Des conjugués de GnRH (hormones libérant l'hormone lutéinisante) sont construits à partir de GnRH ou d'un analogue de celle-ci, à partir d'une exotoxine de Pseudomonas réduite ou d'un variant de cell-ci, et à partir d'un groupe de liaison unique. Ces conjugués sont administrés à des animaux mâles et femelles pour les stériliser ou pour réduire les tumeurs qui ont besoin de stéroïdes sexuels pour croître. Ces conjugués sont par conséquent utiles comme agents stérilisants et comme agents anticancéreux.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NZ321394EP0859624JPH11514380CA2235510AU1996074717