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1. (WO1997015308) COMPOSITIONS AND METHODS FOR TREATING BONE DEFICIT CONDITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015308 International Application No.: PCT/US1996/017019
Publication Date: 01.05.1997 International Filing Date: 23.10.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
A61K 31/47 (2006.01) ,A61K 31/549 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
549
having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
Applicants:
ZYMOGENETICS, INC. [US/US]; 1201 Eastlake Avenue East Seattle, WA 98102, US
OSTEOSCREEN, INC. [US/US]; Suite 201 2040 Babcock Road San Antonio, TX 78229, US
UNIVERSITY OF TEXAS AT AUSTIN [US/US]; Austin, TX, US
Inventors:
PETRIE, Charles; US
ORME, Mark, W.; US
BAINDUR, Nand; US
ROBBINS, Kirk, G.; US
HARRIS, Scott, M.; US
KONTOYIANNI, Maria; US
HURLEY, Laurence, H.; US
KERWIN, Sean, M.; US
MUNDY, Gregory, R.; US
Agent:
MURASHIGE, Kate, H. ; Morrison & Foerster L.L.P. 2000 Pennsylvania Avenue, N.W. Washington, DC 20006-1888, US
Priority Data:
60/005,83023.10.1995US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING BONE DEFICIT CONDITIONS
(FR) COMPOSITIONS ET PROCEDES POUR LE TRAITEMENT DES DEFICITS OSSEUX
Abstract:
(EN) Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or 'linker' defined as including a covalent bond $i(per se) so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.
(FR) L'invention porte sur des composés à deux systèmes aromatiques, liés par covalence par un liant à un ou plusieurs atomes ou par un liant défini comme incluant $i(per se) une liaison covalente espaçant les systèmes aromatiques d'une distance comprise entre 1,5 et 15 Å, et s'avérant efficaces pour le traitement des états liés à un déficit osseux. Lesdits composés s'administrent à des vertébrés, seuls ou associés à des additifs qui favorisent la croissance osseuse ou inhibent la résorption osseuse. On peut en évaluer l'activité avant administration en vérifiant leur capacité à effectuer la transcription d'un gène reporter couplé à un promoteur associé à une protéine morphogénétique osseuse et/ou leur capacité à stimuler la croissance de la voûte crânienne dans des systèmes de modèles animaux.
Designated States: AL, AM, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, FI, GE, HU, IL, IS, JP, KG, KP, KR, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1998-1153NO19981810MXPA/a/1998/003131IL124140EP0866710JP2000513324
CN1201393CA2235481EA199800393KR1019990067010AU1996074710