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1. (WO1997015296) BUCCAL DELIVERY OF GLUCAGON-LIKE INSULINOTROPIC PEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015296 International Application No.: PCT/US1996/016890
Publication Date: 01.05.1997 International Filing Date: 22.10.1996
Chapter 2 Demand Filed: 21.05.1997
IPC:
A61K 9/00 (2006.01) ,A61K 38/26 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
26
Glucagons
Applicants:
THERATECH, INC. [US/US]; Suite 100 417 Wakara Way Salt Lake City, UT 84108, US
Inventors:
HEIBER, Sonia, J.; US
EBERT, Charles, D.; US
GUTNIAK, Mark, K.; SE
Agent:
HOWARTH, Alan, J. ; Thorpe, North & Western, L.L.P. Suite 200 9035 South 700 East Sandy, UT 84070, US
Priority Data:
08/553,80723.10.1995US
Title (EN) BUCCAL DELIVERY OF GLUCAGON-LIKE INSULINOTROPIC PEPTIDES
(FR) APPORT BUCCAL DE PEPTIDES INSULINOTROPIQUES DU TYPE GLUCAGON
Abstract:
(EN) Drug delivery systems and methods for administering a glucagon-like insulinotropic peptide to the buccal mucosa for transmucosal drug delivery are described. The drug delivery systems comprise a drug composition containing an effective amount of the glucagon-like insulinotropic peptide and an effective amount of a permeation enhancer for enhancing permeation of glucagon-like insulinotropic peptide through the buccal mucosa and means for maintaining the drug composition in a drug transferring relationship with buccal mucosa. These systems can be in free form, such as creams, gels, and ointments, or can comprise a device of determined physical form, such as tablets, patches, and troches. A preferred glucagon-like insulinotropic peptide is GLP-1(7-36)amide.
(FR) Systèmes d'apport de médicament et procédés d'administration d'un peptide insulinotropique du type glucagon sur la muqueuse buccale pour apporter le médicament à travers la muqueuse. Les systèmes d'apport de médicament comprennent une composition de médicament contenant une quantité efficace du peptide insulinotropique du type glucagon et une quantité efficace d'une accélération de pénétration qui permet d'améliorer la pénétration du peptide insulinotropique du type glucagon à travers la muqueuse buccale et un système permettant de maintenir la composition du médicament afin d'assurer le transfert du médicament à travers la muqueuse buccale. Les systèmes peuvent se présenter sous forme de crèmes, de gels ou d'onguents ou bien sous une forme solide telle que des comprimés, des patches ou des pastilles. Un peptide insulinotropique du type glucagon préféré est le GLP-1(7-36)amide.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1998/003137EP0859606US5863555JPH11513982 AR04521CN1202820
CA2235369KR1019990064288AU1996074647