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1. (WO1997015293) METHOD OF PRODUCING MULTI-LAYER MEDICAMENTS IN SOLID FORM FOR ORAL OR RECTAL ADMINISTRATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015293 International Application No.: PCT/EP1996/004601
Publication Date: 01.05.1997 International Filing Date: 23.10.1996
Chapter 2 Demand Filed: 22.05.1997
IPC:
A61J 3/10 (2006.01) ,A61K 9/20 (2006.01) ,A61K 9/24 (2006.01) ,A61K 9/28 (2006.01) ,A61K 31/07 (2006.01) ,A61K 31/167 (2006.01) ,A61K 31/192 (2006.01) ,A61K 31/277 (2006.01) ,A61K 31/355 (2006.01) ,A61K 31/375 (2006.01) ,A61K 31/401 (2006.01) ,A61K 31/4422 (2006.01) ,A61K 31/52 (2006.01) ,A61K 31/522 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
J
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3
Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
10
into the form of compressed tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
24
Layered or laminated unitary dosage forms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
28
Dragees; Coated pills or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
07
Retinol compounds, e.g. vitamin A
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
277
having a ring, e.g. verapamil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
355
Tocopherols, e.g. vitamin E
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
375
Ascorbic acid, i.e. vitamin C; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401
Proline; Derivatives thereof, e.g. captopril
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4422
1,4-Dihydropyridines, e.g. nifedipine, nicardipine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
522
having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
Applicants:
BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Ludwigshafen, DE (AllExceptUS)
BREITENBACH, Jörg [DE/DE]; DE (UsOnly)
HÄRTL, Axel, Paul [DE/DE]; DE (UsOnly)
HOFMANN, Jürgen [DE/DE]; DE (UsOnly)
ROSENBERG, Joerg [DE/DE]; DE (UsOnly)
SCHIESSL, Michael [DE/DE]; DE (UsOnly)
ZETTLER, Hans, Dieter [DE/DE]; DE (UsOnly)
Inventors:
BREITENBACH, Jörg; DE
HÄRTL, Axel, Paul; DE
HOFMANN, Jürgen; DE
ROSENBERG, Joerg; DE
SCHIESSL, Michael; DE
ZETTLER, Hans, Dieter; DE
Agent:
REITSTÖTTER, KINZEBACH & PARTNER; Postfach 86 06 49 D-81633 München, DE
Priority Data:
195 39 361.923.10.1995DE
Title (DE) VERFAHREN ZUR HERSTELLUNG VON MEHRSCHICHTIGEN, FESTEN ARZNEIFORMEN ZUR ORALEN ODER REKTALEN VERABREICHUNG
(EN) METHOD OF PRODUCING MULTI-LAYER MEDICAMENTS IN SOLID FORM FOR ORAL OR RECTAL ADMINISTRATION
(FR) PROCEDE DE PREPARATION DE FORMES GALENIQUES SOLIDES MULTICOUCHES POUR ADMINISTRATION ORALE OU RECTALE
Abstract:
(DE) Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung mehrschichtiger, fester Arzneiformen zur oralen oder rektalen Verabreichung, wobei man mindestens zwei Massen, die jeweils ein thermoplastisches, pharmakologisch akzeptables und in physiologischer Umgebung lösliches oder quellbares polymeres Bindemittel umfassen und von denen wenigstens eine einen pharmazeutischen Wirkstoff enthält, koextrudiert und das koextrudierte mehrschichtige Material zu der gewünschten Arzneiform formt.
(EN) The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.
(FR) L'invention concerne un procédé de préparation de formes galéniques solides multicouches, pour administration orale ou rectale. Selon ce procédé, au moins deux matières qui contiennent chacune un liant polymère thermoplastique, pharmacologiquement acceptable, et soluble ou pouvant gonfler dans un environnement physiologique, et dont au moins une contient un principe actif pharmaceutique, sont coextrudées. Le matériau multicouche coextrudé est ensuite moulé pour prendre la forme galénique voulue.
Designated States: AU, BG, BR, CA, CN, CZ, HU, IL, JP, KR, MX, NO, NZ, PL, RU, SG, SI, SK, TR, UA, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
CZPV1998-1242NO19981793ES2175139EP0857062US6120802JPH11513697
CN1200033CA2232356PT857062KR1019990066978DK0857062AU1996074912
MYPI 96004363BG102313