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1. (WO1997015288) METHOD AND PREPARATIONS FOR STABILIZING BIOLOGICAL MATERIALS BY DRYING METHODS WITHOUT FREEZING
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015288 International Application No.: PCT/EP1996/004627
Publication Date: 01.05.1997 International Filing Date: 24.10.1996
Chapter 2 Demand Filed: 01.02.1997
IPC:
A61K 38/18 (2006.01) ,A61K 38/19 (2006.01) ,A61K 38/44 (2006.01) ,A61K 47/18 (2006.01) ,A61K 47/26 (2006.01) ,F26B 5/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
44
Oxidoreductases (1)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
F MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
26
DRYING
B
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
5
Drying solid materials or objects by processes not involving the application of heat
04
by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
Applicants:
BOEHRINGER MANNHEIM GMBH [DE/DE]; D-68298 Mannheim, DE (AllExceptUS)
MATTERN, Markus [DE/DE]; DE (UsOnly)
WINTER, Gerhard [DE/DE]; DE (UsOnly)
Inventors:
MATTERN, Markus; DE
WINTER, Gerhard; DE
Common
Representative:
BOEHRINGER MANNHEIM GMBH; Patentabteilung D-68298 Mannheim, DE
Priority Data:
195 39 574.325.10.1995DE
Title (DE) ZUBEREITUNGEN UND VERFAHREN ZUR STABILISIERUNG BIOLOGISCHER MATERIALIEN MITTELS TROCKNUNGSVERFAHREN OHNE EINFRIEREN
(EN) METHOD AND PREPARATIONS FOR STABILIZING BIOLOGICAL MATERIALS BY DRYING METHODS WITHOUT FREEZING
(FR) PREPARATIONS ET PROCEDES POUR STABILISER DES MATERIAUX BIOLOGIQUES A L'AIDE DE PROCEDES DE DESSICCATION SANS CONGELATION
Abstract:
(DE) Die vorliegende Erfindung betrifft Verfahren zur Herstellung von trockenen, teilamorphen, biologisches, insbesondere therapeutisch aktives Material enthaltenden Produkten, die makroskopisch homogene Substanzgemische darstellen, wobei die Substanzgemische ausgewählt sind aus je mindestens einer Substanz der Gruppe (i) Kohlenhydrat oder Zwitterion mit polarem Rest und deren Derivate, und (ii) Zwitterion mit apolarem Rest und dessen Derivate, dadurch gekennzeichnet, daß eine Lösung des biologischen oder therapeutisch aktiven Materials und der Substanzen (i) und (ii) hergestellt wird und die Lösung bei einer Produkttemperatur oberhalb des Gefrierpunktes der Lösung getrocknet wird. Ferner betrifft die Erfindung neue Substanzgemische, die durch das genannte Verfahren erhalten werden, sowie deren Verwendung in diagnostischen oder therapeutischen Verfahren.
(EN) The invention concerns a method of producing dry partially amorphous products containing biological, in particular therapeutically active, material, the products comprising macroscopically homogeneous substance mixtures. The substance mixtures are selected from at least one substance of the group comprising: (i) carbohydrate or zwitterion with a polar residue and its derivatives; and (ii) zwitterion with an apolar residue and its derivatives. The method is characterized in that a solution of the biologically or therapeutically active material and substances (i) and (ii) is produced and dried at a product temperature above the freezing point of the solution. The invention further concerns novel substance mixtures obtained by the above method and their use in diagnostic or therapeutic processes.
(FR) L'invention concerne un procédé de préparation de produits secs partiellement amorphes contenant un matériau biologique ayant notamment une action thérapeutique, qui présentent des mélanges de substances homogènes sur le plan macroscopique. Les mélanges de substances sont sélectionnés parmi au moins une des substances du groupe (i) hydrate de carbone ou zwitterion à reste polaire et ses dérivés, et (ii) zwitterion à reste apolaire et ses dérivés. Ce procédé se caractérise en ce qu'une solution comprenant le matériau biologique ou à action thérapeutique et les substances (i) et (ii) est préparée, puis est desséchée à une température du produit supérieure au point de congélation de ladite solution. L'invention concerne en outre de nouveaux mélanges de substances obtenus à l'aide dudit procédé, ainsi que leur utilisation dans des méthodes diagnostiques ou thérapeutiques.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
CZPV1998-1179NO19981868SK50998TR1998/00715SG53245IL124204
ES2170274EP0857060JP2007236975RU02191003US20010055617US20030059468
US20070020289JPH11513700CN1205628CA2235243PT857060KR1019990067082
NZ320276AU1996072984DK0857060