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1. (WO1997015190) THROMBIN INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/015190 International Application No.: PCT/US1996/016865
Publication Date: 01.05.1997 International Filing Date: 21.10.1996
Chapter 2 Demand Filed: 06.05.1997
IPC:
A61K 38/00 (2006.01) ,C07D 207/16 (2006.01) ,C07K 5/02 (2006.01) ,C07K 5/06 (2006.01) ,C07K 5/065 (2006.01) ,C07K 5/078 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
16
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
02
containing at least one abnormal peptide link
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
065
the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
06
Dipeptides
078
the first amino acid being heterocyclic, e.g. Pro, His, Trp
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
LUMMA, William, C. [US/US]; US (UsOnly)
TUCKER, Thomas, J. [US/US]; US (UsOnly)
WITHERUP, Keith, M. [US/US]; US (UsOnly)
BRADY, Stephen, F. [US/US]; US (UsOnly)
WHITTER, Willie, L. [US/US]; US (UsOnly)
VACCA, Joseph, P. [US/US]; US (UsOnly)
COBURN, Craig [US/US]; US (UsOnly)
SHAFER, Jules, A. [US/US]; US (UsOnly)
Inventors:
LUMMA, William, C.; US
TUCKER, Thomas, J.; US
WITHERUP, Keith, M.; US
BRADY, Stephen, F.; US
WHITTER, Willie, L.; US
VACCA, Joseph, P.; US
COBURN, Craig; US
SHAFER, Jules, A.; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/006,07624.10.1995US
60/023,16405.08.1996US
9605163.612.03.1996GB
Title (EN) THROMBIN INHIBITORS
(FR) INHIBITEURS DE THROMBINE
Abstract:
(EN) A compound which inhibits human thrombin and where has the structure (I) such as (II).
(FR) La présente invention concerne un composé qui inhibe la thrombine humaine et qui a la structure (I), comme par exemple (II).
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0858262JPH11514378 CA2233860AU1996074634