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1. (WO1997014793) NUCLEIC ACID CLAMPS

Pub. No.:    WO/1997/014793    International Application No.:    PCT/US1996/014411
Publication Date: Apr 24, 1997 International Filing Date: Sep 10, 1996
IPC: C12N 15/11
C12Q 1/68
Applicants: TRUSTEES OF BOSTON UNIVERSITY
Inventors: FRANK-KAMENETSKII, Maxim, D.
VESELKOV, Alexei, G.
DEMIDOV, Vadim, V.
Title: NUCLEIC ACID CLAMPS
Abstract:
The invention relates to nucleic acid clamps and methods for using nucleic acid clamps, for example, to inhibit gene expression or cleavage, or to specifically cleave a target nucleic acid. Nucleic acid clamps are molecular devices which can bind nucleic acids with affinity and specificity and have a recognition sequence as small as seven bases. Nucleic acid clamps can be used to modify the effective recognition sequence of restriction endonucleases, reducing the frequency and enhancing the length of the recognition sequence, but without diminishing specificity. The invention also relates to methods for the use of nucleic acid clamps for the treatment of disorders involving abnormal gene expression.