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1. (WO1997012872) ACRIDONE COMPOUNDS

Pub. No.:    WO/1997/012872    International Application No.:    PCT/JP1996/002880
Publication Date: Apr 10, 1997 International Filing Date: Oct 3, 1996
IPC: C07D 219/14
Applicants: EISAI CO., LTD.

MIYAMOTO, Mitsuaki

YOSHIUCHI, Tatsuya

SATO, Keizo

KAINO, Makoto

TAKASHIMA, Yoshihiro

MORIYA, Katsuhiro

SAKUMA, Yoshinori

YAMADA, Koji

HARADA, kOkichi

NISHIZAWA, Yukio

KOBAYASHI, Seiichi

OKITA, Makoto

KATAYAMA, Koichi

Inventors: MIYAMOTO, Mitsuaki

YOSHIUCHI, Tatsuya

SATO, Keizo

KAINO, Makoto

TAKASHIMA, Yoshihiro

MORIYA, Katsuhiro

SAKUMA, Yoshinori

YAMADA, Koji

HARADA, kOkichi

NISHIZAWA, Yukio

KOBAYASHI, Seiichi

OKITA, Makoto

KATAYAMA, Koichi

Title: ACRIDONE COMPOUNDS
Abstract:
Novel acridone compounds represented by general formula (I) or pharmacologically acceptable salts thereof efficacious in the prevention and treatment of diseases in which chemical transmitters (histamine, leukotriene, etc.) participate, typified by asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, digestive tract allergy, food allergy, etc., wherein R?1, R2, R3, R4, R5 and R6¿ are the same or different and each represents hydrogen, hydroxy, halogeno, lower alkyl, cycloalkyl, lower alkoxy, etc.; Y represents -(CH¿2?)t-(B)m-(CH2)-Z [wherein m is 0 or 1; t and n represent each an integer of from 0 to 6; B represents lower alkylene, optionally substituted arylene, etc.; and Z represents cyano, optionally protected carboxy, acyl or -NR?7R8¿ (wherein R?7 and R8¿ are the same or different and each represents hydrogen, lower alkyl, lower alkoxy, hydroxyalkyl, etc.)]; and D represents oxygen or sulfur.