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1. (WO1997012620) METHOD AND COMPOSITION FOR TREATMENT OF OSTEOPOROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/012620    International Application No.:    PCT/US1996/015594
Publication Date: 10.04.1997 International Filing Date: 27.09.1996
Chapter 2 Demand Filed:    02.05.1997    
IPC:
A61K 31/66 (2006.01), A61K 31/675 (2006.01), A61K 33/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 22nd floor, 300 Lakeside Drive, Oakland, CA 94612 (US).
MARDER, Herman, L. [US/US]; (US)
Inventors: MARDER, Herman, L.; (US).
MORRIS, R., Curtis, Jr.; (US).
SEBASTIAN, Anthony; (US)
Agent: PARMELEE, Steven, W.; Townsend and Townsend and Crew L.L.P., 8th floor, Two Embarcadero Center, San Francisco, CA 94111 (US)
Priority Data:
60/005,397 06.10.1995 US
08/649,039 16.05.1996 US
Title (EN) METHOD AND COMPOSITION FOR TREATMENT OF OSTEOPOROSIS
(FR) PROCEDE ET COMPOSITION SERVANT A TRAITER L'OSTEOPOROSE
Abstract: front page image
(EN)The combination of the following active agents for treating osteoporosis: (a) a pharmacologically-acceptable alkalinizing potassium salt which produces hydroxyl ions and is thereby capable of reducing the acidity of tissue fluids or urine and which is selected from the group consisting of potassium bicarbonate and potassium salts of carboxylic acids which are metabolized to bicarbonate and thus alkalinize $i(in vivo); and (b) a bisphosphonate which is effective as an antiresorptive agent for bone in the treatment of osteoporosis; the active ingredients being administered in amounts effective to treat osteoporosis without adversely affecting bone and acid-base homeostatis.
(FR)Combinaison des agents actifs suivants dans le but de traiter l'ostéoporose: (a) sel de potassium alcalinisant acceptable en pharmacologie produisant des ions hydroxyle et, de ce fait, capable de limiter l'acidité de liquides tissulaires et de l'urine et sélectionné dans le groupe constitué par bicarbonate de potassium et par des sels de potassium d'acides carboxyliques métabolisés en bicarbonate et, devenant, par conséquent, alcalins in vivo; (b) bicarbonate efficace en tant qu'inhibiteur de la résorption osseuse dans le traitement de l'ostéoporose; les ingrédients actifs étant administrés en quantités suffisantes pour traiter l'ostéoporose sans exercer d'effets adverses sur l'os et sur l'homéostasie acide-base.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)