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1. (WO1997012052) TRANSDUCTION OF HEMATOPOIETIC CELLS BY VIRAL VECTOR AND A CATIONIC LIPID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/012052    International Application No.:    PCT/US1996/015580
Publication Date: 03.04.1997 International Filing Date: 27.09.1996
Chapter 2 Demand Filed:    15.04.1997    
IPC:
A61K 9/127 (2006.01), A61K 48/00 (2006.01), C12N 9/16 (2006.01), C12N 15/87 (2006.01)
Applicants: TARGETED GENETICS CORPORATION [US/US]; Suite 100, 1100 Olive Way, Seattle, WA 98101 (US) (For All Designated States Except US).
ANKLESARIA, Pervin [IN/US]; (US) (For US Only).
LYNCH, Carmel, M. [IE/US]; (US) (For US Only)
Inventors: ANKLESARIA, Pervin; (US).
LYNCH, Carmel, M.; (US)
Agent: DYLAN, Tyler, M.; Morrison & Foerster L.L.P., 755 Page Mill Road, Palo Alto, CA 94304-1018 (US).
GOLDIN, Douglas, Michael; J.A. Kemp & Co., 14 South Square, Gray's Inn, London WC1R 5LX (GB)
Priority Data:
60/004,477 28.09.1995 US
08/572,331 14.12.1995 US
60/015,665 19.04.1996 US
Title (EN) TRANSDUCTION OF HEMATOPOIETIC CELLS BY VIRAL VECTOR AND A CATIONIC LIPID
(FR) TRANSDUCTION DE CELLULES HEMATOPOIETIQUES PAR VECTEUR VIRAL ET LIPIDE CATIONIQUE
Abstract: front page image
(EN)The present invention provides methods for the high efficiency transduction of hematopoietic cells that involve exposing the cells to combinations of viral vectors and cationic lipid adjuvants. Among hematopoietic cells, the methods are especially useful for the transduction of pluripotent hematopoietic stem cells (PHSCs) which have been difficult to transduce with high efficiency.
(FR)L'invention porte sur des procédés de transdution à haut rendement de cellules hématopoïétiques, qui consistent à exposer lesdites cellules à des combinaisons de vecteurs viraux et d'adjuvants lipidiques cationiques. Ces procédés sont particulièrement utiles pour la transduction, parmi d'autres cellules hématopoïétiques, de cellules souches hématopoïétiques pluripotentes, dont la transduction n'était auparavant pas effectuée avec un rendement élevé.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)