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1. (WO1997011198) RAPID AND SENSITIVE ASSAYS FOR DETECTING AND DISTINGUISHING BETWEEN PROCESSIVE AND NON-PROCESSIVE TELOMERASE ACTIVITIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/011198    International Application No.:    PCT/US1996/015162
Publication Date: 27.03.1997 International Filing Date: 20.09.1996
Chapter 2 Demand Filed:    21.04.1997    
IPC:
C12Q 1/68 (2006.01)
Applicants: CTRC RESEARCH FOUNDATION [US/US]; 8122 Data Point Drive, San Antonio, TX 78229 (US)
Inventors: WINDLE, Bradford, E.; (US).
QIU, Ming; (US).
CHEN, Shih-Fong; (US).
FLETCHER, Terace, M.; (US).
MAINE, Ira; (US)
Agent: HIGHLANDER, Steven, L.; Arnold, White & Durkee, P.O. Box 4433, Houston, TX 77210 (US)
Priority Data:
08/531,743 20.09.1995 US
Title (EN) RAPID AND SENSITIVE ASSAYS FOR DETECTING AND DISTINGUISHING BETWEEN PROCESSIVE AND NON-PROCESSIVE TELOMERASE ACTIVITIES
(FR) DOSAGES RAPIDES ET SENSIBLES DE DETECTION ET DE DISCRIMINATION ENTRE LES ACTIVITES PROCESSIVES ET NON PROCESSIVES DE LA TELOMERASE
Abstract: front page image
(EN)Improved telomerase activity assays are provided in which a ligation sequential reaction (LSR) or BrdUTP are used to identify a telomerase specific product. These assays are useful in diagnosing various cancers and determining the clinical prospects for cancer patients. In addition, the assays can be used to screen for substances that interfere with telomerase activity.
(FR)L'invention porte sur des dosages améliorés relatifs à l'activité de la télomérase dans lesquels on recourt à une réaction séquentielle de liaison (LSR) ou à un BrdUTP (bromo-désoxyuridine triphosphate) pour identifier un produit spécifique de la télomérase. Ces dosages permettent de diagnostiquer différents types de cancers et de déterminer les perspectives cliniques des patients qui en sont atteint. Ils peuvent également servir au criblage de substances perturbant l'activité de la télomérase.
Designated States: AL, AM, AT, AU, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)