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Machine translation
1. (WO1997011178) HUMAN GROWTH HORMONE VARIANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/011178    International Application No.:    PCT/US1996/014830
Publication Date: 27.03.1997 International Filing Date: 20.09.1996
Chapter 2 Demand Filed:    21.04.1997    
IPC:
A61K 38/00 (2006.01), C07K 14/61 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 460 Point San Bruno Boulevard, South San Francisco, CA 94080-4990 (US) (For All Designated States Except US).
CUNNINGHAM, Brian, C. [US/US]; (US) (For US Only).
LOWMAN, Henry, B. [US/US]; (US) (For US Only).
WELLS, James, A. [US/US]; (US) (For US Only).
CLARK, Ross, G. [NZ/US]; (US) (For US Only).
OLSON, Kenneth [US/US]; (US) (For US Only).
FUH, Germaine, G. [--/US]; (US) (For US Only)
Inventors: CUNNINGHAM, Brian, C.; (US).
LOWMAN, Henry, B.; (US).
WELLS, James, A.; (US).
CLARK, Ross, G.; (US).
OLSON, Kenneth; (US).
FUH, Germaine, G.; (US)
Agent: HALIDAY, Emily, M.; Skjerven, Morrill, MacPherson, Franklin & Friel, Suite 700, 25 Metro Drive, San Jose, CA 95110 (US).
BALDOCK, Sharon, Claire; Boult Wade Tennant, 27 Furnival Street, London EC4Q 1PQ (GB)
Priority Data:
537,067 21.09.1995 US
537,068 21.09.1995 US
Title (EN) HUMAN GROWTH HORMONE VARIANTS
(FR) VARIANTS DE L'HORMONE DE CROISSANCE HUMAINE
Abstract: front page image
(EN)Human growth hormone variants are disclosed having enhanced affinity for the growth hormone receptor. Also disclosed are human growth hormone variants conjugated to one or more chemical groups, such as poly(ethylene glycol), which is believed to prolong the $i(in vivo) half-life of the variants.
(FR)La présente invention concerne des variants de l'hormone de croissance humaine qui ont une affinité accrue pour le récepteur de l'hormone de croissance. L'invention concerne aussi des variants conjugués à un ou plusieurs groupes chimiques, comme le poly(éthylène glycol), dont on croit qu'il prolonge la demi-vie $i(in vivo) de ces variants.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)