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1. (WO1997008300) CRYSTALLINE ZAP FAMILY PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/008300    International Application No.:    PCT/US1996/013918
Publication Date: 06.03.1997 International Filing Date: 30.08.1996
Chapter 2 Demand Filed:    26.03.1997    
IPC:
C12N 9/12 (2006.01)
Applicants: ARIAD PHARMACEUTICALS, INC. [US/US]; 26 Landsdowne Street, Cambridge, MA 02139 (US)
Inventors: HATADA, Marcos, H.; (US).
LU, Xiaode; (US).
LAIRD, Ellen, R.; (US).
KARAS, Jennifer, L.; (US).
ZOLLER, Mark, J.; (US).
HOLT, Dennis, A.; (US)
Agent: BERSTEIN, David, L.; Ariad Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, MA 02139 (US)
Priority Data:
60/002,972 30.08.1995 US
60/003,312 06.09.1995 US
Title (EN) CRYSTALLINE ZAP FAMILY PROTEINS
(FR) PROTEINES CRISTALLINES DE LA FAMILLE ZAP
Abstract: front page image
(EN)The invention relates to human ZAP-70, and in particular, to the region of ZAP-70 containing the tandem Src homology-2 ('SH2') domains, to crystalline forms thereof, liganded or unliganded, which are particularly useful for the determination of the three-dimensional structure of the protein. The three-dimensional structure of the tandem SH2 region of ZAP provides information useful for the design of pharmaceutical compositions which inhibit the biological function of ZAP and other members of the ZAP family of SH2 domain-containing proteins, particularly those biological functions mediated by molecular interactions involving one or both SH2 domains.
(FR)L'invention concerne la ZAP-70 de l'homme et, en particulier, la région de ZAP-70 contenant les domaines tandem d'homologie-2 de Src ('SH2'), ses formes cristallines, à ligand ou sans ligand, qui sont particulièrement utiles pour déterminer la structure tridimensionnelle de la protéine. La structure tridimensionnelle de la région tandem de SH2 de la ZAP fournit des informations utiles à la conception de compositions pharmaceutiques inhibant la fonction biologique de la ZAP et d'autres membres de la famille ZAP de protéines contenant les domaines de SH2, en particulier les fonctions biologiques induites par des interactions moléculaires impliquant un ou deux domaines de SH2.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)