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Machine translation
1. (WO1997008182) PROCESS FOR THE PREPARATION OF IMIDAZOLYL MACROLIDE IMMUNOSUPPRESSANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/008182    International Application No.:    PCT/US1996/013609
Publication Date: 06.03.1997 International Filing Date: 20.08.1996
Chapter 2 Demand Filed:    11.03.1997    
IPC:
C07H 19/01 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
MATHRE, David, J. [US/US]; (US) (For US Only).
SHUMAN, Richard, F. [US/US]; (US) (For US Only).
SOHAR, Paul [US/US]; (US) (For US Only).
SONG, Zhiguo [CN/US]; (US) (For US Only)
Inventors: MATHRE, David, J.; (US).
SHUMAN, Richard, F.; (US).
SOHAR, Paul; (US).
SONG, Zhiguo; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/002,726 24.08.1995 US
9603378.2 16.02.1996 GB
Title (EN) PROCESS FOR THE PREPARATION OF IMIDAZOLYL MACROLIDE IMMUNOSUPPRESSANTS
(FR) PROCEDE DE PREPARATION D'IMMUNOSUPPRESSEURS MACROLIDES A BASE D'IMIDAZOLYLE
Abstract: front page image
(EN)Imidazolmethyloxy-substituted tricyclo-macrolide immunosuppressants are prepared by reacting a tricyclo-macrolide with an imidazolmethyl trichloroacetimidate in the presence of an acid. The invention further provides a crystalline salt of imidazolmethyloxy-substituted tricyclo-macrolide, as well as novel compounds useful in the process of the present invention.
(FR)L'invention se rapporte à un procédé de préparation d'immunosuppresseurs tricyclo-macrolides à base d'imidazolméthyloxy substitué qui consiste à faire réagir un tricyclo-macrolide avec un trichloroacétimidate d'imidazolméthyle trichloroacétimidate en présence d'un acide. L'invention se rapporte également à un sel cristallin de tricyclo-macrolide imidazolméthyloxy substitué ainsi qu'à de nouveaux composés utiles au procédé de la présente invention.
Designated States: AL, AM, AU, AZ, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)