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1. (WO1997007788) COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT

Pub. No.:    WO/1997/007788    International Application No.:    PCT/US1996/013787
Publication Date: Mar 6, 1997 International Filing Date: Aug 29, 1996
IPC: A61K 9/16
A61K 9/50
Applicants: ALKERMES CONTROLLED THERAPEUTICS, INC.
LEE, Hye-Jung
JOHNSON, OluFunmi, L.
ZALE, Stephen, E.
TRACY, Mark, A.
Inventors: LEE, Hye-Jung
JOHNSON, OluFunmi, L.
ZALE, Stephen, E.
TRACY, Mark, A.
Title: COMPOSITION FOR SUSTAINED RELEASE OF AN AGENT
Abstract:
Composition for the sustained release of a biologically active agent in vivo. The composition comprises microcarriers containing a first solid-phase biocompatible material and a biologically active agent, wherein said microcarriers sustain in vivo release of the biologically active agent. The composition also contains particles of a second biocompatible solid-phase material wherein the second solid-phase material further sustains the in vivo release of the biologically active agent. The invention also relates to a method for sustaining effective serum levels of a biologically active agent in a subject, including forming an injectable dose containing an effective amount of a biologically active agent, wherein the agent is contained in a microcarrier, with a release-period sustaining amount of a solid-phase material. The method further includes administering the injectable dose to the subject.