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|1. (WO1997007787) ORAL CYCLOSPORIN FORMULATIONS|
|Applicants:||SANGSTAT MEDICAL CORPORATION
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
|Inventors:||CHO, Moo, J.
LEVY, Ralph, E.
POULETTY, Philippe, J.
|Title:||ORAL CYCLOSPORIN FORMULATIONS|
Improved oral cyclosporin formulations which have high bioavailability and are capable of administration in hard capsules or nanoparticles are provided. In the subject formulations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formulations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno-suppressive therapy.