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1. (WO1997006435) IMPROVEMENTS IN OR RELATING TO METHODS OF SCREENING SUBSTANCES

Pub. No.:    WO/1997/006435    International Application No.:    PCT/GB1996/001905
Publication Date: Feb 20, 1997 International Filing Date: Aug 5, 1996
IPC: G01N 33/50
Applicants: MEDICAL RESEARCH COUNCIL
RUSSELL, Stephen, James
MORLING, Frances, Joanne
PENG, Kah-Whye
Inventors: RUSSELL, Stephen, James
MORLING, Frances, Joanne
PENG, Kah-Whye
Title: IMPROVEMENTS IN OR RELATING TO METHODS OF SCREENING SUBSTANCES
Abstract:
Disclosed is a method of screening substances for reduced ability to bind to a specified target molecule. The method involves the display of a first member of a specific binding pair ('sbp') on the surface of a viral display package, and contacting the viral display package with a target cell expressing a receptor molecule and the second member of the sbp in such a way that viral display packages displaying first members of the sbp which have been altered so as to inhibit binding to the second member of the sbp tend to infect target cells more successfully than those display packages displaying first members of the sbp which have unaltered binding affinity for the second member of the sbp. Also disclosed is a kit for use in performing the method of the invention.