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Machine translation
1. (WO1997006255) MAMMALIAN APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, PROBES AND DETECTION METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/006255    International Application No.:    PCT/IB1996/001022
Publication Date: 20.02.1997 International Filing Date: 05.08.1996
Chapter 2 Demand Filed:    27.02.1997    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01), C12Q 1/68 (2006.01)
Applicants: UNIVERSITY OF OTTAWA [CA/CA]; 550 Cumberland, Ottawa, Ontario K1N 6N5 (CA) (For All Designated States Except US).
KORNELUK, Robert, G. [CA/CA]; (CA) (For US Only).
MACKENZIE, Alexander, E. [CA/CA]; (CA) (For US Only).
BAIRD, Stephen [CA/CA]; (CA) (For US Only).
LISTON, Peter [CA/CA]; (CA) (For US Only)
Inventors: KORNELUK, Robert, G.; (CA).
MACKENZIE, Alexander, E.; (CA).
BAIRD, Stephen; (CA).
LISTON, Peter; (CA)
Agent: MORROW, Joy, D.; Smart & Biggar, 900 - 55 Metcalfe Street, P.O. Box 2999, Station D, Ottawa, Ontario K1P 5Y6 (CA)
Priority Data:
08/511,485 04.08.1995 US
08/576,956 22.12.1995 US
Title (EN) MAMMALIAN APOPTOSIS INHIBITOR PROTEIN GENE FAMILY, PRIMERS, PROBES AND DETECTION METHODS
(FR) FAMILLE DE GENES MAMMALIENS DE PROTEINES INHIBANT L'APOPTOSE (IAP), AMORCES, SONDES ET PROCEDES DE DETECTION
Abstract: front page image
(EN)Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.
(FR)L'invention concerne un type ADN sensiblement pur codant des polypeptides mammaliens (IAP), des polypeptides sensiblement purs et des procédés relatifs à l'utilisation de ce type d'ADN en vue d'exprimer les polypeptides IAP dans les cellules et chez les animaux lorsqu'il s'agit d'inhiber l'apoptose. On décrit par ailleurs des régions conservées caractéristiques de la famille des IAP ainsi que des amorces et des sondes permettant d'identifier et d'isoler des gènes IAP supplémentaires. On décrit aussi des procédés pour le traitement des affections et des troubles impliquant l'apoptose.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)