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Machine translation
1. (WO1997005132) AMINOACYL ADENYLATE MIMICS AS NOVEL ANTIMICROBIAL AND ANTIPARASITIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/005132    International Application No.:    PCT/US1996/011910
Publication Date: 13.02.1997 International Filing Date: 18.07.1996
Chapter 2 Demand Filed:    13.02.1997    
IPC:
C07D 405/06 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01), C07D 417/14 (2006.01), C07D 493/04 (2006.01)
Applicants: CUBIST PHARMACEUTICALS, INC. [US/US]; 24 Emily Street, Cambridge, MA 02139 (US)
Inventors: HILL, Jason, M.; (US).
YU, Guixue; (US).
SHUE, Youe-Kong; (US).
ZYDOWSKY, Thomas, M.; (US).
REBEK, Julius, Jr.; (US)
Agent: PLUMER, Elizabeth, R.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210 (US)
Priority Data:
60/001,649 28.07.1995 US
60/014,881 04.04.1996 US
08/683,809 16.07.1996 US
Title (EN) AMINOACYL ADENYLATE MIMICS AS NOVEL ANTIMICROBIAL AND ANTIPARASITIC AGENTS
(FR) ANALOGUES DE L'ADENYLATE D'AMINOACYLE EN TANT QU'AGENTS ANTIMICROBIENS ET ANTIPARASITES NOUVEAUX
Abstract: front page image
(EN)Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is [S-(R*,R*)]-3,6-anhydro-1,2-dideoxy-1-[5-[4-[(5-nitro-2-thienyl)ethynyl]phenyl]-2H-tetrazol-2-yl]-D-allo-heptitol 7-(2-amino-3-methyl-1-oxopentyl)sulfamate. These compounds inhibit isoleucyl-tRNA synthetases and are useful as antimicrobial and antiparasitic agents.
(FR)On décrit certains nouveaux analogues de l'adénylate d'aminoacyle. A titre d'exemple, un composé de l'invention est un [S-(R*,R*]-3,6-anhydro-1,2-didésoxy-1-[5-[4-[(5-nitro-2-thiényl)éthynyl]phényl]-2H-tétrazol-2yl]-D-allo-heptitol 7-(2-amino-3-méthyl-1-oxopentyl)sulfamate. Ces composés inhibent les isoleucyle-ARNt synthétases et ils sont utiles en tant qu'agents antimicrobiens et antiparasites.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)