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1. (WO1997004710) METHOD FOR THE COMMINUTION OF CONCRETIONS

Pub. No.:    WO/1997/004710    International Application No.:    PCT/US1996/009874
Publication Date: Feb 13, 1997 International Filing Date: Jun 10, 1996
IPC: A61B 17/00
A61B 17/22
Applicants: DUKE UNIVERSITY
Inventors: ZHONG, Pei
COCKS, Franklin, H.
PREMINGER, Glenn, M.
Title: METHOD FOR THE COMMINUTION OF CONCRETIONS
Abstract:
The invention relates to a method for the comminution of concretions in vivo by controlled, concentrated cavitation energy. This method utilizes two shock wave pulses (7, 8) with a specified time delay (3) and pressure relationship, with the first shock wave pulse (7) being used to induce a transient cavitation bubble cluster (9) near the target concretion (4), and the second shock wave pulse (8) to control and force the collapse of the cavitation bubble cluster towards the target concretion (4) with concentrated energy disposition, while avoiding injury to surrounding tissue caused by random collapse of the cavitation bubbles (9). This invention makes it possible to significantly enhance the fragmentation efficiency of the concretion using shock waves while reducing potential deleterious injury to surrounding tissue.