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1. (WO1997003695) METHODS FOR DETECTING, IDENTIFYING, ISOLATING, AND SELECTIVELY LABELLING AND TARGETING TH1 LYMPHOCYTES BY MEANS OF THE LAG-3 PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/003695    International Application No.:    PCT/US1996/011994
Publication Date: 06.02.1997 International Filing Date: 19.07.1996
Chapter 2 Demand Filed:    19.02.1997    
IPC:
C12N 15/09 (2006.01), A01N 1/02 (2006.01), A01N 63/00 (2006.01), A61K 31/00 (2006.01), A61K 35/26 (2006.01), A61K 35/66 (2006.01), A61K 38/00 (2006.01), A61K 39/395 (2006.01), A61K 45/00 (2006.01), A61P 31/00 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), B01D 15/08 (2006.01), B01D 43/00 (2006.01), B01D 57/00 (2006.01), B03C 1/00 (2006.01), C07K 14/705 (2006.01), C07K 16/00 (2006.01), C07K 16/28 (2006.01), C12N 15/02 (2006.01), C12N 5/00 (2006.01), C12N 5/0783 (2010.01), C12P 21/08 (2006.01), G01N 33/53 (2006.01), G01N 33/536 (2006.01), G01N 33/553 (2006.01), G01N 33/569 (2006.01)
Applicants: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. [NL/NL]; 14, John B. Gorsiraweg, P.O. Box 3889, Curacao (AN) (For All Designated States Except US).
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE [FR/FR]; 101, rue de Tolbaic, F-75654 Paris Cédex 13 (FR) (For All Designated States Except US).
INSTITUT GUSTAVE ROUSSY [FR/FR]; Rue Camille-Desmoulins, F-94805 Villejuif Cédex (FR) (For All Designated States Except US).
ROMAGNANI, Sergio [IT/IT]; (IT) (For US Only).
MCINNIS, Patricia, A. [US/US]; (US) (VN only)
Inventors: ROMAGNANI, Sergio; (IT)
Agent: BROWDY, Roger, L.; Browdy and Neimark, P.L.L.C., Suite 300, 419 Seventh Street, N.W., Washington, DC 20004 (US)
Priority Data:
60/001,367 21.07.1995 US
60/002,683 21.09.1995 US
Title (EN) METHODS FOR DETECTING, IDENTIFYING, ISOLATING, AND SELECTIVELY LABELLING AND TARGETING TH1 LYMPHOCYTES BY MEANS OF THE LAG-3 PROTEIN
(FR) PROCEDES POUR DETECTER, IDENTIFIER, ISOLER, MARQUER ET CIBLER SELECTIVEMENT LES LYMPHOCYTES TH1, AU MOYEN DE LA PROTEINE LAG-3
Abstract: front page image
(EN)The lymphocyte activation gene (LAG-3) is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. Surface LAG-3 expression correlated with IFN-$g(g) but not IL-4, production in antigen-stimulated T-cells and it was up-regulated by IL-12 and is preferentially associated with CD4+ T-cells producing Th1-type cytokines. The presence of LAG-3 on the surface of Th1 lymphocytes is used as a marker to detect and identify Th1 lymphocytes and differentiate them from Th2 lymphocytes. Monoclonal antibodies to LAG-3 are used in methods of detecting and isolating Th1 cells as well as methods of diagnosing Th1-mediated disease. The present invention also relates to methods of treating infectious diseases, cancer, and disorders associated with Th1/Th2 imbalance.
(FR)Le gène d'activation des lymphocytes (LAG-3), qui est un membre de la superfamille des immunoglobulines, est transcrit sélectivement dans les lymphocytes T et les cellules tueuses naturelles activées de l'homme. Il y a une corrélation entre l'expression de la protéine de surface LAG-3 et la production d'IFN-$g(g) dans les lymphocytes T stimulés par un antigène, mais pas celle d'IL-4, et cette production est stimulée par IL-12. Cette production est associée, de préférence, avec les lymphocytes T CD4+ produisant des cytokines du type Th-1. La présence de LAG-3 sur la surface des lymphocytes Th1 est utilisée comme marqueur pour détecter et identifier les lymphocytes Th1 et les distinguer des lymphocytes Th2. On utilise des anticorps monoclonaux dirigés contre LAG-3 pour détecter et isoler les cellules Th1, ainsi que pour diagnostiquer des maladies associées à Th1. La présente invention concerne également des procédés de traitement de maladies infectieuses, du cancer et de troubles associés à un déséquilibre Th1/Th2.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)