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1. WO1996041881 - TYPE F BOTULINUM TOXIN AND USE THEREOF

Publication Number WO/1996/041881
Publication Date 27.12.1996
International Application No. PCT/GB1996/001409
International Filing Date 12.06.1996
Chapter 2 Demand Filed 13.01.1997
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 1/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
14Extraction; Separation; Purification
16by chromatography
22Affinity chromatography or related techniques based upon selective absorption processes
C07K 14/33 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
33from Clostridium (G)
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07K 1/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
14Extraction; Separation; Purification
16by chromatography
22Affinity chromatography or related techniques based upon selective absorption processes
C07K 14/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
33from Clostridium (G)
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • MICROBIOLOGICAL RESEARCH AUTHORITY [GB]/[GB] (AllExceptUS)
  • ELMORE, Michael, James [GB]/[GB] (UsOnly)
  • MAUCHLINE, Margaret, Lamble [GB]/[GB] (UsOnly)
  • MINTON, Nigel, Peter [GB]/[GB] (UsOnly)
  • PASECHNIK, Vladimir, Artymovich [GB]/[GB] (UsOnly)
  • TITBALL, Richard, William [GB]/[GB] (UsOnly)
Inventors
  • ELMORE, Michael, James
  • MAUCHLINE, Margaret, Lamble
  • MINTON, Nigel, Peter
  • PASECHNIK, Vladimir, Artymovich
  • TITBALL, Richard, William
Agents
  • SCHLICH, George, William
Priority Data
9511909.512.06.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TYPE F BOTULINUM TOXIN AND USE THEREOF
(FR) TOXINE BOTULINIQUE DE TYPE F ET SON UTILISATION
Abstract
(EN)
A polypeptide free of toxin activity gives protection against botulinum type F toxin. A fusion protein of a fragment of a toxin molecule and a purification moeity enables purification of the fragment from solution. Pharmaceutical compositions containing the polypeptide and the fusion protein are described.
(FR)
Un polypeptide dépourvu d'activité toxinique présente une protection contre la toxine botulinique de type F. Une protéine de fusion d'un fragment d'une molécule de toxine ainsi qu'une fraction de purification permettent la purification du fragment à partir de la solution. L'invention se rapporte également aux compositions pharmaceutiques contenant le polypeptide et la protéine de fusion.
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