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1. WO1996041628 - GRANULES CONTAINING PRANLUKAST, PROCESS FOR PRODUCING THE GRANULES, AND METHOD OF LOWERING COHESIVENESS OF PRANLUKAST

Publication Number WO/1996/041628
Publication Date 27.12.1996
International Application No. PCT/JP1996/001578
International Filing Date 11.06.1996
Chapter 2 Demand Filed 26.12.1996
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
A61K 31/41 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
CPC
A61K 31/41
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
A61K 9/1623
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
A61K 9/1635
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1635obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
A61K 9/1641
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
A61K 9/1652
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Applicants
  • ONO PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • SASATANI, Seiei [JP]/[JP] (UsOnly)
  • SHIOTA, Masashi [JP]/[JP] (UsOnly)
  • II, Yoshinori [JP]/[JP] (UsOnly)
Inventors
  • SASATANI, Seiei
  • SHIOTA, Masashi
  • II, Yoshinori
Agents
  • OHIE, Kunihisa
Priority Data
7/16929212.06.1995JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) GRANULES CONTAINING PRANLUKAST, PROCESS FOR PRODUCING THE GRANULES, AND METHOD OF LOWERING COHESIVENESS OF PRANLUKAST
(FR) GRANULES CONTENANT DU PRANLUKAST, PROCEDE DE PRODUCTION DES GRANULES ET PROCEDE DE REDUCTION DE LA COHESION DU PRANLUKAST
Abstract
(EN)
Spray-dried granules containing pranlukast (A) and at least one saccharide (B) as the essential ingredients and further containing at least one water-soluble polymer (C) and/or at least one surfactant (D). Although pranlukast is endowed with an extremely strong cohesiveness, the process of the invention can efficiently provide granules containing hardly cohesive pranlukast and having a narrow granular size distribution and a good fluidity. The granules can be used for continuously producing capsules, tablets and other products containing the same without posing any problems, and the obtained products can be well disintegrated or dispersed.
(FR)
La présente invention concerne des granules séchés par pulvérisation et contenant du pranlukast (A) et au moins un saccharide (B) en tant que constituants essentiels, et contenant en outre au moins un polymère soluble dans l'eau (C) et/ou au moins un agent tensioactif (D). Bien que le pranlukast présente une cohésion extrêmement forte, le procédé de l'invention peut fournir avec efficacité des granules contenant du pranlukast dont la cohésion est très faible, et présentant une répartition granulométrique étroite et une bonne fluidité. Les granules peuvent être utilisés pour produire en continu des capsules, des comprimés et d'autres produits les contenant, sans que cela pose aucun problème, et les produits obtenus peuvent être aisément désagrégés ou dispersés.
Also published as
Latest bibliographic data on file with the International Bureau