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1. WO1996041144 - POLYOXYHYDROCARBYL MARKER PRODUCTS AND METHODS FOR FLUORESCENCE ASSAYS

Publication Number WO/1996/041144
Publication Date 19.12.1996
International Application No. PCT/US1996/008935
International Filing Date 04.06.1996
Chapter 2 Demand Filed 31.12.1996
IPC
C09B 47/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
47Porphines; Azaporphines
C09B 47/24 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
47Porphines; Azaporphines
04Phthalocyanines
08Preparation from other phthalocyanine compounds
24Obtaining compounds having -COOH or -SO3H radicals, or derivatives thereof, directly bound to the phthalocyanine radical
C09B 69/00 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
69Dyes not provided for by a single group of this subclass
G01N 33/52 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
CPC
A61K 41/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 49/0015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0015Phosphorescence
A61K 49/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
A61K 49/0026
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0026Acridine dyes
A61K 49/0028
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
0021the fluorescent group being a small organic molecule
0028Oxazine dyes
Applicants
  • HYPERION, INC. [US]/[US]
Inventors
  • DANDLIKER, Walter, Beach
  • DEVLIN, Robert, Francis
  • ARRHENIUS, Peter, Olaf, Gustaf
  • HSU, Mao-Lin
Agents
  • BERKMAN, Charles, S.
  • MOON, Donald, keith
Priority Data
08/476,54406.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYOXYHYDROCARBYL MARKER PRODUCTS AND METHODS FOR FLUORESCENCE ASSAYS
(FR) PRODUITS DE MARQUAGE A BASE DE POLYOXYHYDROCARBYLE ET DOSAGES IMMUNOLOGIQUES EN FLUORESCENCE
Abstract
(EN)
Fluorescent dyes copuled to one or more polyoxyhydrocarbyl moieties which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, $i(in vivo) imaging and $i(in vivo) tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed particularly to markers wherein the fluorophore is selected from the group consisting of aryl terminated polymethine dyes; quinoid dyes; 1,4-diaminoanthraquinone-2,3-dicarboxamides, indanthrene dyes; tetraaminoanthraquinones; azine dyes; (thio)pyriliamdyes and napthoquinone methides.
(FR)
L'invention se rapporte à des colorants fluorescents couplés à une ou plusieurs fractions polyoxyhydrocarbyle, lesquelles ne peuvent s'agglomérer ni se lier au sérum. Ces colorants sont appropriés à des applications telles que des dosages immunologiques en fluorescence, l'imagerie $i(in vivo) et la thérapie $i(in vivo) des tumeurs. Ces dosages immunologiques en fluorescence mettent en oeuvre des colorants fluorescents qui ne peuvent s'agglomérer ni se lier au sérum. De tels dosages sont donc particulièrement utiles pour l'analyse de fluides biologiques tels que du sérum, du plasma, du sang entier et de l'urine. La présente invention concerne notamment des marqueurs dans lesquels le fluorophore est choisi dans le groupe constitué par des colorants polyméthiniques à terminaison aryle; des colorants quinoïdiques; des 1,4-diaminoanthraquinone-2,3-dicarboxamides, des colorants indanthréniques; des tétraaminoanthraquinones; des colorants aziniques; des colorants (thio)pyrylium et des méthides naphtoquinoniques.
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