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1. WO1996040883 - NOVEL FACTOR IX PURIFICATION METHODS

Publication Number WO/1996/040883
Publication Date 19.12.1996
International Application No. PCT/US1996/007305
International Filing Date 21.05.1996
Chapter 2 Demand Filed 07.11.1996
IPC
C12N 9/64 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
CPC
C12N 9/644
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6424Serine endopeptidases (3.4.21)
644Coagulation factor IXa (3.4.21.22)
C12Y 304/21022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
304Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
21Serine endopeptidases (3.4.21)
21022Coagulation factor IXa (3.4.21.22)
Applicants
  • GENETICS INSTITUTE, INC. [US]/[US]
Inventors
  • FOSTER, W., Barry
  • COSTIGAN, Robert, J.
  • BONAM, Duane
  • SWITZER, Mary, B.
  • WALSH, Rochelle
Agents
  • MEINERT, M., C.
Priority Data
08/472,82307.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL FACTOR IX PURIFICATION METHODS
(FR) NOUVEAUX PROCEDES DE PURIFICATION DU FACTEUR IX
Abstract
(EN)
Provided by the present invention are novel methods of factor IX protein recovery and purification, making use of anion exchange chromatography heparin-like resins, hydroxyapatite and immobilized metal affinity chromatography.
(FR)
La présente invention a pour objet de nouveaux procédés de purification et de récupération de la protéine du facteur IX.
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