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1. WO1996040878 - MONKEY MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN B7.1 AND/OR B7.2 PRIMATIZED FORMS, PHARMACEUTICAL COMPOSITIONS

Publication Number WO/1996/040878
Publication Date 19.12.1996
International Application No. PCT/US1996/010053
International Filing Date 06.06.1996
Chapter 2 Demand Filed 07.01.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
Applicants
  • IDEC PHARMACEUTICALS CORPORATION [US]/[US]
Inventors
  • ANDERSON, Darrell, R.
  • BRAMS, Peter
  • HANNA, Nabil
  • SHESTOWSKY, William, S.
Agents
  • GESS, E., Joseph
Priority Data
08/487,55007.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONKEY MONOCLONAL ANTIBODIES SPECIFIC TO HUMAN B7.1 AND/OR B7.2 PRIMATIZED FORMS, PHARMACEUTICAL COMPOSITIONS
(FR) ANTICORPS MONOCLONAUX SIMIENS DIRIGES SPECIFIQUEMENT CONTRE LE B7.1 ET/OU B7.2 HUMAINS, LEURS FORMES ADAPTEES AUX PRIMATES, ET COMPOSITIONS PHARMACEUTIQUES
Abstract
(EN)
The present invention relates to the identification of macaque antibodies to human B7.1 and B7.2 by screening of phase display libraries or monkey heterohybridomas obtained using B lymphocytes from B7.1 and/or B7.2 immunized monkeys. More specifically, the invention provides four monkey monoclonal antibodies 7B6, 16C10, 7C10 and 20C9 which inhibit the B7:CD28 pathway and thereby function as effective immunosuppressants. The invention further provides the complete DNA and amino acid sequences of the light and heavy chain of three primatized antibodies derived from those monkey monoclonal antibodies which bind B7.1 and possibly B7.2, primatized 7C10, primatized 7B6 and primatized 16C10. These primatized and monkey antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
(FR)
L'invention concerne l'identification d'anticorps de macaques dirigés contre le B7.1 et B7.2 humains par criblage de bibliothèques de phages ou d'hétérohybridomes simiens obtenus par utilisation de lymphocytes B prélevés sur des singes immunisés contre le B7.1 et/ B7.2. Plus spécifiquement, l'invention concerne quatre anticorps monoclonaux simiens 7B6, 16C10, 7C10 et 20C9 qui inhibent la voie B7:CD28 et agissent par conséquent efficacement comme immunosuppresseurs. L'invention concerne en outre les séquences complètes d'ADN et d'acides aminés des chaînes légère et lourde des trois anticorps adaptés aux primates dérivés de ces anticorps monoclonaux simiens qui se lient au B7.1 et éventuellement au B7.2, au 7C10 adapté aux primates, au 7B6 adapté aux primates et au 16C10 adapté aux primates. On peut utiliser ces anticorps simiens et adaptés aux primates comme immunosuppresseurs spécifiques, par exemple pour traiter des maladies auto-immunes et pour prévenir le rejet d'organes transplantés.
Latest bibliographic data on file with the International Bureau