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1. WO1996040790 - PRESENTATION OF NATIVE ANTIGEN ON BEADS OR OTHER SOLID PHASES

Publication Number WO/1996/040790
Publication Date 19.12.1996
International Application No. PCT/US1996/009381
International Filing Date 07.06.1996
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
CPC
G01N 33/54353
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54353with ligand attached to the carrier via a chemical coupling agent
G01N 33/585
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
585with a particulate label, e.g. coloured latex
Applicants
  • BECTON DICKINSON AND COMPANY [US]/[US]
Inventors
  • DAVIS, Kenneth, A.
  • ABRAMS, Barnaby
  • BISHOP, James, E.
Agents
  • RONNING, Royal, N.
Priority Data
08/438,43707.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRESENTATION OF NATIVE ANTIGEN ON BEADS OR OTHER SOLID PHASES
(FR) PRESENTATION D'ANTIGENE NATIF SUR DES BILLES OU AUTRES PHASES SOLIDES
Abstract
(EN)
This invention presents a rapid simple method for preparing solid phases with antigens or other substituents presented on the surface in such a manner that the antigens/substituents retain their original functionality and conformation, as well as much of their native structure, to permit their use in a wide array of applications. The substituent is isolated from the hydrophobic surface of the bead or orther solid phase by coating the surface with a milk or a milk protein, alone or in combination with linker molecules, thereby preventing interaction of the substituents with the bead surface.
(FR)
Cette invention concerne un procédé simple et rapide de préparation de phases solides présentant des antigènes ou d'autres substituants sur leur surface, et d'une manière telle que ces antigènes ou substituants conservent leur valence fonctionnelle et leur conformation originelles ainsi qu'une grande partie de leur structure native, ce qui permet de les utiliser dans une gamme d'applications étendue. Le substituant est isolé de la surface hydrophobe d'une bille, ou d'une autre phase solide, par enduction de ladite surface de lait ou d'une protéine du lait, seul ou en combinaison avec des molécules de liaison, ce qui permet d'empêcher une interaction entre les substituants et la surface de la bille.
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