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1. WO1996040787 - MONOCLONAL ANTIBODY DETECTION OF PROTEINS ON SPERM RELATED TO FERTILITY

Publication Number WO/1996/040787
Publication Date 19.12.1996
International Application No. PCT/US1996/008961
International Filing Date 07.06.1996
Chapter 2 Demand Filed 06.01.1997
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C07K 14/4723
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4723Cationic antimicrobial peptides, e.g. defensins
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
G01N 2333/4721
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4721Cationic antimicrobial peptides, e.g. defensins
G01N 2400/40
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2400Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
10Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
38Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, e.g. Konjac gum, Locust bean gum, Guar gum
40Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
G01N 2800/367
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
36Gynecology or obstetrics
367Infertility, e.g. sperm disorder, ovulatory dysfunction
G01N 33/689
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
689related to pregnancy or the gonads
Applicants
  • THE UNIVERSITY OF ARIZONA [US]/[US]
Inventors
  • AX, Roy, L.
  • BELLIN, Mary, E.
Agents
  • KUESTERS, Eckhard, H.
Priority Data
08/487,16807.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCLONAL ANTIBODY DETECTION OF PROTEINS ON SPERM RELATED TO FERTILITY
(FR) DETECTION PAR ANTICORPS MONOCLONAUX DE PROTEINES SUR DES SPERMATOZOIDES AFIN DE DETERMINER LA FECONDITE
Abstract
(EN)
Heparin binding proteins (HBP) are produced by male accessory glands and bind to sperm at ejaculation. The ability of accessory glands to produce HBP and sperm to bind HBP differs among males. Identifying the presence of a 21.5, 24 and 30 kDa heparin binding proteins in sperm membranes with a monoclonal antibody resulted in separating groups of bulls by 40 % difference in fertility. Thus, fertility potential of a bull can be predicted by heparin binding protein content of sperm membranes.
(FR)
Des protéines liant l'héparine (HBP) sont produites par les glandes annexes mâles et se lient au sperme lors de l'éjaculation. La faculté des glandes annexes de produire des HBP et du sperme de se lier au HBP diffère selon les mâles. L'identification de la présence de protéines de liaison d'héparine de 21,5, 24 et 30 kDa dans des membranes de spermatozoïdes à l'aide d'un anticorps monoclonal a permis de séparer des groupes de b÷ufs présentant une différence de fécondité de 40 %. Ainsi, il est possible de prédire le potentiel de fécondité d'un b÷uf selon la teneur en protéines de liaison d'héparine de membranes de spermatozoïdes.
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