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1. WO1996040780 - TRANSGLUTAMINASE CROSS-LINKABLE POLYPEPTIDES AND METHODS RELATING THERETO

Publication Number WO/1996/040780
Publication Date 19.12.1996
International Application No. PCT/US1996/008269
International Filing Date 31.05.1996
Chapter 2 Demand Filed 13.12.1996
IPC
A61L 24/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
10Polypeptides; Proteins
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/75 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
75Fibrinogen
CPC
A61L 24/106
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
04containing macromolecular materials
10Polypeptides; Proteins
106Fibrin; Fibrinogen
C07K 14/4732
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4732Casein
C07K 14/75
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
745Blood coagulation or fibrinolysis factors
75Fibrinogen
Applicants
  • ZYMOGENETICS, INC. [US]/[US]
Inventors
  • LABROO, Virender, M.
  • BUSBY, Sharon, J.
Agents
  • SAWISLAK, Deborah, A.
  • LEITH, Debra, K.
Priority Data
08/483,23607.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRANSGLUTAMINASE CROSS-LINKABLE POLYPEPTIDES AND METHODS RELATING THERETO
(FR) POLYPEPTIDES RETICULABLES PAR TRANSGLUTAMINASE ET PROCEDES ASSOCIES
Abstract
(EN)
Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and copolymers disclosed herein are useful in tissue sealant and wound healing formulations.
(FR)
L'invention a pour objet des polypeptides qui sont constitués d'environ 9 à 120 restes d'acides aminés comprenant un segment tronqué de fibrinogène qui peut être flanqué de peptides élastomères, lesdits polypeptides étant réticulables par une transglutaminase, ainsi que des homo et copolymères contenant de tels polypeptides. Les homo et copolymères décrits dans cette invention sont utiles pour des formulations destinées à la fermeture des tissus et à la cicatrisation des plaies.
Also published as
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