Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Saturday 31.10.2020 at 7:00 AM CET
Settings

Settings

Goto Application

1. WO1996040762 - MONOCYTE CHEMOTACTIC PROTEIN-4

Publication Number WO/1996/040762
Publication Date 19.12.1996
International Application No. PCT/US1996/010087
International Filing Date 07.06.1996
Chapter 2 Demand Filed 07.01.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
Applicants
  • HUMAN GENOME SCIENCES, INC. [US]/[US] (AllExceptUS)
  • LI, Haodong [CN]/[US] (UsOnly)
  • RUBEN, Steven, M. [US]/[US] (UsOnly)
  • SUTTON, Granger, G., III [US]/[US] (UsOnly)
Inventors
  • LI, Haodong
  • RUBEN, Steven, M.
  • SUTTON, Granger, G., III
Agents
  • STEFFE, Eric, K.
Priority Data
08/479,12607.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOCYTE CHEMOTACTIC PROTEIN-4
(FR) PROTEINE-4 CHIMIOTACTIQUE DE MONOCYTE
Abstract
(EN)
A human monocyte chemotactic protein-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
(FR)
L'invention décrit un polypeptide de protéine-4 chimiotactique de monocyte humain et un ADN (ARN) codant ce polypeptide, ainsi qu'une opération pour produire ledit polypeptide par des techniques de recombinaison. Elle décrit également des procédés pour utiliser ce polypeptide dans le but de prévenir et/ou de traiter la mobilisation des cellules souches, la myéloprotection et la protection neuronale, de traiter des tumeurs, de favoriser la cicatrisation, de combattre les parasitoses et de réguler l'hématopoïèse. Elle décrit aussi des antagonistes de ces polypeptides qui peuvent être utilisés pour traiter la polyarthrite rhumatoïde, l'inflammation pulmonaire, l'allergie, les maladies infectieuses et pour prévenir l'inflammation et l'athérosclérose. Elle décrit encore des épreuves diagnostiques visant à identifier des mutations dans une séquence d'acide nucléique codant un polypeptide de l'invention ainsi qu'à détecter une modification des taux dudit polypeptide afin de détecter des maladies.
Latest bibliographic data on file with the International Bureau