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1. WO1996040728 - AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS

Publication Number WO/1996/040728
Publication Date 19.12.1996
International Application No. PCT/US1996/010508
International Filing Date 07.06.1996
Chapter 2 Demand Filed 03.01.1997
IPC
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • MAGAININ PHARMACEUTICALS INC. [US]/[US]
Inventors
  • ZASLOFF, Michael
  • SHINNAR, Ann
  • KINNEY, William
  • WILLIAMS, Jon
  • RAO, Meena
  • ANDERSON, Mark
  • MCLANE, Michael
  • JONES, Steven
Agents
  • GARRETT, Arthur, S.
Priority Data
08/475,57207.06.1995US
08/476,85507.06.1995US
08/479,45507.06.1995US
08/479,45707.06.1995US
08/483,05707.06.1995US
08/483,05907.06.1995US
08/487,44307.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS
(FR) COMPOSES D'AMINOSTEROL UTILES COMME INHIBITEURS DE L'ECHANGEUR SODIUM/PROTON (NHE), METHODES ET COMPOSITIONS PHARMACEUTIQUES UTILISANT CES INHIBITEURS, ET PROCEDES D'EVALUATION DE L'EFFICACITE INHIBITRICE DU NHE DESDITS COMPOSES
Abstract
(EN)
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
(FR)
Composés d'aminostérol utiles comme inhibiteurs de l'échangeur sodium/proton (NHE). Sont également décrits des procédés d'utilisation de ces composés d'aminostérols, y compris des procédés prévoyant l'utilisation de composés qui sont des inhibiteurs d'un spectre de NHE et ceux qui utilisent des composés inhibiteurs d'un seul NHE spécifique. L'invention concerne également des techniques et des dosages de décriblage permettant d'évaluer l'activité thérapeutique d'un composé.
Latest bibliographic data on file with the International Bureau