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1. WO1996040700 - MODIFIED $g(a)-D-Glcp-(1-2)-$g(a)-D-Glcp-(1-3)-$g(a)-D-Glcp-ANALOGUES

Publication Number WO/1996/040700
Publication Date 19.12.1996
International Application No. PCT/CA1996/000389
International Filing Date 06.06.1996
Chapter 2 Demand Filed 31.12.1996
IPC
C07H 3/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
04Disaccharides
C07H 3/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
C07H 15/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of a saccharide radical
CPC
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
C07H 15/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02Acyclic radicals, not substituted by cyclic structures
04attached to an oxygen atom of the saccharide radical
C07H 3/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
04Disaccharides
C07H 3/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
Applicants
  • ALBERTA RESEARCH COUNCIL [CA]/[CA] (AllExceptUS)
  • SRIVASTAVA, Om [CA]/[CA] (UsOnly)
  • SZWEDA, Roman [CA]/[CA] (UsOnly)
Inventors
  • SRIVASTAVA, Om
  • SZWEDA, Roman
Agents
  • McMAHON, Eileen
Priority Data
08/485,05707.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODIFIED $g(a)-D-Glcp-(1-2)-$g(a)-D-Glcp-(1-3)-$g(a)-D-Glcp-ANALOGUES
(FR) $g(a)-D-Glcp-(1-2)-$g(a)-D-Glcp-(1-3)-$g(a)-D-Glcp-ANALOGUES MODIFIES
Abstract
(EN)
Human immunodeficiency viruses (HIV-1 and HIV-2) are known to be the etiological agents of acquired immunodeficiency syndrome (AIDS). The carbohydrate structures on the virus coat proteins, gp120, are necessary for cell-cell fusion. The oligosaccharides on gp120 are processed by the enzyme glycosidase. The trisaccharide, $g(a)-D-Glcp-(1-2)-$g(a)-D-Glcp-(1-3)-$g(a)-D-GlcpO(CH2)8COOMe and its analogues modified at its terminal glucose residues are recognized by the enzyme and can inhibit glycosylation.
(FR)
On sait que les virus de l'immunodéficience humaine (VIH-1 et VIH-2) sont des agents étiologiques du syndrome d'immunodéficience acquise (SIDA). Les structures glucide situées sur les protéines de coque de virus, les gp120, sont nécessaires pour la fusion cellule-cellule. Les oligosaccharides situés sur les gp120 sont remaniés par l'enzyme glycosidase. Le trisaccharide, $g(a)-D-Glcp-(1-2)-$g(a)-D-Glcp-(1-3)-$g(a)-D-GlcpO(CH2)8COOMe et ses analogues modifiés au niveau des ses résidus glucose terminaux sont reconnus par l'enzyme et peuvent inhiber la glycosylation.
Also published as
Latest bibliographic data on file with the International Bureau